高血压脑出血患者肿瘤坏死因子-α、血管内皮生长因子、内皮素-1与其血肿组织的相关性研究

Correlation between tumor necrosis factor-alpha,vascular endothelial growth factor,endothelin-1 and hematoma in patients with hypertensive intracerebral hemorrhage

目的探讨高血压脑出血患者肿瘤坏死因子-α(TNF-α)、血管内皮生长因子(VEGF)、内皮素-1(ET-1)与其血肿组织的相关性。方法选自该院于2015年1月至2016年12月期间收治的高血压脑出血患者53例(观察组),收集同期该院尸检正常脑组织标本50例(对照组)。采用免疫组织化学法检测正常脑组织和高血压脑出血血肿周围组织TNF-α、VEGF、ET-1表达情况。结果观察组TNF-α阳性表达率(88.68%)高于对照组(16.00%),且差异有统计学意义(P<0.05);观察组VEGF阳性表达率(86.79%)高于对照组(12.00%),且差异有统计学意义(P<0.05);观察组ET-1阳性表达率(83.02%)高于对照组(18.00%),且差异有统计学意义(P<0.05)。结论高血压脑出血患者TNF-α、VEGF、ET-1在血肿周围组织中高表达,呈正相关,具有重要研究意义。

Objective To investigate the relationship between tumor necrosis factor alpha（TNF-α）,vascular endothelial growth factor（VEGF）,endothelin-1（ET-1）and hematoma in patients with hypertensive intracerebral hemorrhage.Methods A total of 53 patients with hypertensive intracerebral hemorrhage（observation group）were selected from a hospital from January 2015 to December 2016 year,and 50 cases the normal brain tissue specimens（control group）were collected from the same period in our hospital.Immunohistochemical method was used to detect the expression of TNF-α,VEGF and ET-1 in the brain tissues of normal brain tissue and hypertensive intracerebral hemorrhage.Results The observation group TNF-αpositive expression rate（88.68%）higher than that of the control group（16.00%,P〈0.05）;the observation group the positive expression rate of VEGF（86.79%）was higher than the control group（12.00%,P〈0.05）;the observation group the positive expression rate of ET-1（83.02%）was higher than the control group（18.00%,P〈0.05）.Conclusion The expression of TNF-α,VEGF and ET-1 in hypertensive intracerebral hemorrhage patients is highly correlated with the surrounding tissues,which is of great significance.