血浆NT-proBNP、左心室重量指数在老年左心室射血分数正常心力衰竭患者临床诊断中的应用价值

The clinical value of plasma NT-proBNP and left ventricular mass index in the diagnosis of elderly patients with normal heart failure of left ventricular ejection fraction

目的探讨老年左心室射血分数正常的心力衰竭(HFNEF)患者,血浆N末端脑钠肽前体(NTproBNP)、左心室重量指数(LVMI)变化,分析其在HFNEF诊断中的应用价值。方法选取该院就诊的HFNEF患者99例,左心室射血分数降低的心力衰竭(HFREF)患者47例,健康体检自愿者60例,对其血浆NTBNP、LVMI进行检测,分析对比其检测结果。结果对照组LVMI检测结果为(85.51±20.25)g/m2,HFNEF组LVMI检测结果为(126.96±25.81)g/m2,HEREF组LVMI检测结果为(135.25±36.22)g/m2(P<0.05);对照组血浆NT-proBNP检测结果低于HFNEF组、HEREF组,HFNEF组血浆NT-proBNP检测结果低于HEREF组(P<0.05);随心功能级别增长,血浆NT-proBNP、LVMI水平表现为随之增长(P<0.05);血浆NT-proBNP、LVMI在HFNEF诊断中曲线下面积分别为0.967、0.885;血浆NT-proBNP与LVMI相关性分析(r=0.502,P<0.01)。结论 HFNEF患者诊断中,血浆NT-BNP、LVMI具有较高应用价值,且两者呈现为正相关,值得推广。

Objective To investigate the changes of plasma N terminal pro brain natriuretic peptide（（NTproBNP）and left ventricular mass index（LVMI）in elderly patients with normal left ventricular ejection fraction（heart failure,HFNEF）,and analyze their application value in HFNEF diagnosis.Methods 99 patients with HFNEF,47 patients with heart failure（HFREF）with reduced left ventricular ejection fraction and 60 healthy volunteers were selected.The plasma NT-BNP and LVMI were detected,and the results were compared.Results The control group LVMI test results for（85.51±20.25）g/m2,HFNEF group LVMI test results for（126.96±25.81）g/m2,HEREF group LVMI test results for（135.25±36.22）g/m2,（P〈0.05）;the control group plasma NT-proBNP detection results of lower than that in HFNEF group,HEREF group,HFNEF group,plasma NT-proBNP test results lower than that of HEREF group（P〈0.05）;heart function level growth,plasma NT-proBNP,LVMI level is increased（P〈0.05）;plasma NT-proBNP,LVMI in the diagnosis of HFNEF in the area under the curve were 0.967,0.885;BNP and LVMI plasma NT-pro correlation analysis r=0.502（P〈0.01）.Conclusion In the diagnosis of HFNEF,plasma NT-BNP and LVMI have high application value,and they are positive correlation.It is worth popularizing.