原发性开角型青光眼与血流异常的关系

The relationship between primary open angle glaucoma and blood flow abnormalities

原发性开角型青光眼（POAG）作为青光眼的常见类型，发病隐匿，并存在患者眼压不高却伴有青光眼性视神经损害或眼压降低至正常范围后疾病仍处于进展状态的情况，相应的病程控制和疾病预防也仍是难点。本文主要对POAG患者存在的眼部及全身血流异常情况，包括眼部血流高阻低流、血管密度减少，全身血流调控能力降低、血液流变学改变、血压和甲皱襞微循环的异常情况进行总结，分析、归纳血流异常引起青光眼性视神经损害的作用机制。加强对POAG发病机制中血流学说的认识，为今后POAG的研究提供新思路。

As one of the common types of glaucoma, primary open angle glaucoma （POAG） occurs insidiously with conditions, such as patients have normal intraocular pressure while accompanying with glaucomatous optic nerve damage, or the intraocular pressure is reduced to normal range, while the disease is still progressing.Additionally, the control and prevention of corresponding disease remain difficult.This paper summarized the ocular and systemic blood flow abnormalities in POAG, including high resistance and low flow rate of the ocular blood, reduction of vascular density in the eye, systemic vascular dysregulation, hemorheology change, as well as abnormalities in blood pressure and nailfold microcirculation.Keeping in mind the impact of these abnormalities on the occurrence and development of POAG, this paper analyzed the mechanism of glaucomatous optic nerve damage caused by abnormal blood flow and strengthened the understanding of blood flow theory in the pathogenesis of POAG.The ultimate goal is providing a novel thought for future research in POAG.