基于脑网络信息传递特性的癫痫病灶区定位

Epileptogenic focus localization through information transfer characteristic based on brain networks

目的癫痫是一种反复发作的慢性脑疾病,严重危害患者身心健康。如何精确定位癫痫病灶区是目前医学研究热点之一。本文旨在基于脑网络信息传递特性定位癫痫病灶区,期望为临床确诊病灶区提供创新思路。方法应用频域因果连接分析构建5位颞叶癫痫患者颅内脑电特征频段因果网络,计算网络节点因果流。结果 (1)颞叶癫痫患者颅内脑电能量分布优势频带是δ、θ频段,δ、θ频段能量显著高于其他频段,病灶区能量分布高于非病灶区。(2)颞叶癫痫患者病灶区因果流小于0,非病灶区因果流大于0。结论 (1)颞叶癫痫患者颅内脑电特征频段为δ、θ,病灶区特征频段能量异常增强。(2)颞叶癫痫患者因果网络中,被定义为因果汇的脑区为临床确诊病灶区,因果源脑区为非病灶区,病灶区易受非病灶区影响。

Objective Epilepsy is a chronic and relapsing brain disease,and severely threatens physical and mental health of the patients.How to precisely locate the epileptogenic focus has become a new hotpoint of medical research.The aim of this paper is to locate the epileptogenic focus through information transfer characteristic based on brain networks,and to provide new insights for epileptogenic focus localization.Methods The experimental data are intracranial EEGs obtained from 5 patients with temporal lobe epilepsy.The causality analysis in frequency domain is applied to construct causality network of the characteristic frequency bands of EEGs and compute causal flow of network nodes.Results（1） The advantage of the energy distribution of EEG in the patients with temporal lobe epilepsy are delta and theta frequency,the energy of delta and theta frequency are greater compared to the other bands.The energy in the focus are greater compared to the corresponding bands in the non-focus.（2） Causal flow value in the focus of temporal lobe epilepsy is less than 0,while in the non-focus is greater than 0.Conclusions（1） The characteristic frequency bands ofEEG in temporal lobe epilepsy are δ and θ.The energy of the two characteristic frequency bands in the focus are abnormally increased.（2） In the causality network of temporal lobe epilepsy,the brain area that is defined as a causal sink is the clinical focus and the area that is defined as a causal source is the clinical non-focus.The focus is likely to be easily influenced by the non-focus.