芪参益气滴丸对首次急性ST段抬高型前壁心肌梗死病人PCI术后hs-CRP水平及短期心功能的影响

Effect of Qishen Yiqi Dripping Pills on the hs-CRP Level and Short-term Cardiac Function in Patients with the First Acute ST-Segment Elevation Anterior Myocardial Infarction after PCI

目的探讨芪参益气滴丸对首次急性ST段抬高型前壁心肌梗死病人经冠状动脉介入术(PCI)术后超敏C反应蛋白(hs-CRP)水平及短期心功能的影响。方法将98例病人随机分为两组,对照组(n=50)行常规治疗,治疗组(n=48)在常规治疗基础上加用芪参益气滴丸治疗,两组均治疗2个月。观察两组治疗前后左室舒张末期内径(LVEDD)、左室收缩末期内径(LVESD)、左室射血分数(LVEF)、每分输出量(CO)、心脏指数(CI)、血清N端脑钠肽前体(NT-proBNP)及hs-CRP含量。结果两组病人治疗后LVEDD、LVESD均有缩小,LVEF提高(P<0.05),且治疗后NT-proBNP及hs-CRP水平均下降(P<0.05);治疗后治疗组较对照组心功能恢复更好,血清NT-proBNP、hs-CRP含量有进一步下降(P<0.05)。结论在常规治疗基础上联合芪参益气滴丸治疗急性心肌梗死可进一步改善病人短期心功能,降低血清NT-proBNP、hs-CRP水平,其作用机制可能与芪参益气滴丸抑制炎性因子hs-CRP有关。

Objective To investigate the effect of Qishen Yiqi Dripping pills（QYDP）on the high-sensitivity C-reactive protein（hs-CRP）level and short-term cardiac function in patients with the first acute ST-segment elevation anterior myocardial infarction（STEMI）after percutaneous coronary intervention（PCI）.Methods Ninety-eight patients with acute STEMI after PCI were randomly divided into two groups：control group（n =50）treated with routine treatment and treatment group（n =48）treated with QYDP in the basis of routine treatment for 2 months.The left ventricular end-diastolic diameter（LVEDD）and end-systolic diameter（LVESD）,left ventricular ejection fraction（LVEF）,cardiac output（CO）,and cardiac index（CI）,N-terminal pro-B-type natriuretic peptide（NT-proBNP）,and hs-CRP content were observed before and after treatment.Results LVEDD and LVESD decreased,and LVEF increased in two group after treatment（P 〈0.05）.The concentrations of serum NT-proBNP and hs-CRP were decreased in two groups after treatment（P 〈0.05）.The heart function was better in treatment group than that in control group（P〈 0.05）.The concentrations of serum NT-proBNP and hs-CRP were lower in treatment group than those in control group（P 〈0.05）.Conclusion QYDP and routine treatment can improve the shortterm cardiac function,reduce serum NT-proBNP,hs-CRP levels in patients with acute STEMI after PCI,and its mechanism may be related to inhibiting inflammatory factors hs-CRP.