Notch信号在变应性鼻炎发病中的作用及机制研究进展

The research progress of function and mechanism of Notch signaling pathway in allergy rhinitis

变应性鼻炎(AR)是特应性个体接触过敏原后由IgE介导的Ⅰ型超敏反应,其发病过程中包括了众多炎性细胞和CD4^+T细胞亚群的相互作用。近年来AR发病率逐年攀升,给社会带来了沉重的负担。Notch信号被发现参与到免疫细胞的增殖分化过程中,并与免疫系统疾病密切相关,且其各受体、配体发挥的作用不尽相同。传统药物治疗及过敏原特异性免疫疗法均有一定的局限性,文章就Notch信号各蛋白在AR发病过程中的作用机制进行综述,希望为AR的免疫调控机制和治疗方法开辟新的途径。

Allergy rhinitis is a type of I type hypersensitivity reaction mediated by IgE after idiopathic individual exposure to allergens, and its pathogenesis includes the interaction of numerous inflammatory cells and CD4^＋ T cell subsets. In present, the incidence of AR has been increasing year by year and with a heavy burden to society. The Notch signaling pathway is involved in immune cell differentiation process, which closely related to immune system diseases and its receptors and ligands play different roles. Traditional drug and desensitization therapy still have some limitations. In this review, the mechanism of Notch signaling in the AR pathogenesis is highlighted, hoping to open up a new way for ARs immune mechanism and treatment.