血清胃蛋白酶原检测在胃疾病诊断中的应用价值

Application value of serum pepsinogen(PG) detection in diagnosis of gastric diseases

目的:观察血清胃蛋白酶原(PG)检测在胃疾病诊断中的应用价值。方法:回顾性分析273例胃疾病患者的临床资料,其中胃溃疡44例,慢性萎缩性胃炎67例,慢性浅表性胃炎45例,十二指肠溃疡59例,胃癌58例,每一类型患者均作为一组。另选取同期健康体检者197例作为对照组。采用放射免疫分析法测定血清PGⅠ和PGⅡ水平,比较各组PGⅠ、PGⅡ水平和PGⅠ/PGⅡ。结果:与对照组相比,胃溃疡和十二指肠溃疡组患者血清PGⅠ和PGⅡ水平均较高(P<0.05),PGⅠ/PGⅡ较小(P<0.05),慢性萎缩性胃炎和胃癌组患者血清PGⅠ和PGⅠ/PGⅡ均较小(P<0.05),浅表性胃炎组患者PGⅠ、PGⅡ水平与对照组比较,差异无统计学意义(P>0.05)。结论:患者血清PGⅠ、PGⅡ水平和PGⅠ/PGⅡ与胃黏膜病变关系密切,对胃疾病的诊断具有重要意义。

cases of gastric ulcer, 67 cases of chronic atrophic gastritis, 45 cases of chronic superficial gastritis, 59 cases of duodenal ulcer and 58 cases of gastric cancer. Each disease type was used as a group. Another 197 healthy people for physical examinations were selected as control group. Serum PGI and PGII levels were determined by radioimmunoassay, and the levels of PGI, PGII levels and PGI/PGII were compared among these groups. Results： Compared with the control group, the serum levels of PGⅠ and PGⅡ were significantly higher in the gastric ulcer group and duodenal ulcer group and PGⅠ/PGⅡ was less （ P 〈0.05）, the serum PGⅠ levels and PGⅠ/PGⅡ in the chronic atrophic gastritis group and gastric cancer group were smaller （ P 〈0.05）. However, there were no statistical differences in the PGⅠ level and PGⅠ/PGⅡ between the chronic superficial gastritis group and the control group （ P 〉0.05）. Conclusions： The serum PGI and PGII levels as well as PGI/PGII are closely related to gastric mucosal lesions in the patients with gastric diseases, which is of great significance for the diagnosis of gastric diseases.