糖皮质激素在儿童难治性肺炎支原体肺炎中的应用评价

Application of glucocorticoid in children with refractory Mycoplasma pneumoniae pneumonia

目的探讨糖皮质激素在儿童难治性肺炎支原体肺炎中的应用效果。方法将2017年1月—2018年3月在我院及协作医院儿科诊断为难治性肺炎支原体肺炎40例患儿纳入研究,利用随机数字表抽取样本,均分为观察组和对照组各20例。观察组采取阿奇霉素、甲泼尼龙、泼尼松片治疗,对照组在观察组基础上加用丙种球蛋白治疗,比较2组患儿治疗效果、住院时间、临床症状改善时间、不良反应发生情况。结果 2组治疗效果无统计学差异(P>0.05);2组住院时间及临床症状改善时间无统计学差异(P>0.05);2组患儿均未发生明显不良反应。结论糖皮质激素在儿童难治性肺炎支原体肺炎中效果较好,患儿临床症状改善较快,无明显不良反应,是否加用丙种球蛋白并不影响治疗效果。

Objective Toexplore the application effect ofglucocorticoid in children with refractory Mycoplasma pneumoniae pneumonia.Methods 40 cases of refractory Mycoplasma pneumoniae pneumonia in our hospital from January 2017 to March 2018 were studied.The samples were selected by random number table and divided into the observation group and the control group,20 cases in each group. The observation group was treated with azithromycin,methylprednisolone,prednisone,and the control group was treated with gamma globulin on the basis of the observation group.The therapeutic effect,length of stay,improvement time of clinical symptoms and adverse reactions were compared between the two groups.Results There was no statistical difference in the treatment effect between the two groups（P〉0.05）.There was no statistical difference between the two groups of hospitalization time and the improvement time of clinical symptoms（P〉0.05）.All the two groups had no obvious adverse reactions.Conclusion The effect of glucocorticoid in children with refractory Mycoplasma pneumoniae pneumonia is better,the clinical symptoms of children are improved quickly,no obvious adverse reaction,and whether using gamma globulin does not affect the effect of treatment.