染色体多态性对辅助生殖临床结局的影响

Influence of Chromosomal Polymorphism on Clinical Outcomes of Assisted Reproduction

目的:探讨不孕不育夫妇染色体多态性与辅助生殖临床结局的关系。方法:回顾性分析2015年9月—2016年11月在我院生殖医学中心接受体外受精/胞浆内单精子注射-胚胎移植(IVF/ICSI-ET)助孕1318对不孕不育夫妇的临床资料,将其中一方染色体多态的夫妇作为研究组,双方染色体均正常的夫妇作为对照组,同时按照夫妇中一方染色体多态的性别进行进一步分组,分析染色体多态性及不同性别染色体多态对IVF/ICSI-ET临床结局的影响。结果:染色体多态组患者既往流产史的比例高于染色体核型正常组(24.64%vs.15.65%,P=0.007);男方染色体多态的夫妇高评分囊胚形成率低于女方染色体多态组(18.11%vs.29.03%,P=0.016)及对照组(18.11%vs.23.81%,P=0.017)。结论:染色体多态性患者有更高的流产病史,男方染色体多态性的夫妇的胚胎发育潜力较低,但其IVF/ICSI-ET结局与正常人群相似。

Objective：To explore the relationship between chromosomal polymorphism of the infertile couples and the outcomes of IVF/ICSI-ET. Methods： The chromosome karyotype analysis of 1 318 infertile couples received IVF/ICSI-ET was performed in our center from September 2015 to November 2016. The couples with either male or female chromosome polymorphism were enrolled as the study group,while the couples with normal chromosome karyotypes were served as the control group. The outcomes of IVF/ICSI-ET of two groups were compared. Results： The occurrence of miscarriage history in the study group was significantly higher than that in the control group（24.64% vs. 15.65%, P =0.007）. The rate of high-grade blastocysts in the male polymorphic couple was significantly lower than that in the woman′s chromosomal polymorphism（18.11% vs. 29.03%, P=0.016）or the control group（18.11% vs. 23.81%, P =0.017）. Conclusions： The infertile couples with chromosomal polymorphism have higher rate of previous miscarriage history, and the embryos from male chromosomal polymorphism might have relatively low development potential. However, their outcomes of IVF/ICSI-ET are similar to those with normal chromosome karyotypes.