普罗帕酮与胺碘酮治疗心律失常的效果对比

Effect comparison of Propafenone and Amiodarone treating arrhythmia

目的比较普罗帕酮与胺碘酮治疗心律失常的效果。方法选取2015年2月~2017年12月在我院接诊处理的72例心律失常患者,采用随机数字表将患者分为对照组与观察组,每组36例。对照组给予普罗帕酮治疗,观察组给予胺碘酮治疗。连续治疗5周,比较两组患者的治疗效果、心率变异性(HRV)参数以及用药安全性。结果观察组的总有效率为97.2%,高于对照组的77.8%(P<0.05)。观察组治疗后的HRV参数高于对照组(P<0.05)。观察组的不良反应总发生率为5.6%,低于对照组的22.2%(P<0.05)。结论胺碘酮相对于普罗帕酮在治疗心律失常方面,更具有优势,能够兼顾临床治疗效果以及用药安全性,帮助患者纠正心律失常问题,在排除用药禁忌证的情况下可优先考虑使用。

Objective To compare the effect of Propafenone and Amiodarone treating arrhythmia.Methods A total of 72 patients with arrhythmias treated in our hospital from February 2015 to December 2017 were selected.The patients were divided into control group and observation group using the random digital table method,and there were 36 cases in each group.The control group was treated with Propanone,while the observation group was treated with Amiodarone.Continuous treatment lasted for 5 weeks,the therapeutic effect,heart rate variability（HRV） parameter and drug safety were compared between the two groups.Results The total effective rate in the observation group was 97.2%,which was higher than that in the control group（77.8%）（P〈0.05）.The HRV parameter in the observation group was higher than that in the control group（P〈0.05）.The incidence of adverse reactions in the observation group was 5.6%,which was lower than that in the control group（22.2%）（P〈0.05）.Conclusion Amiodarone has more advantages compared with Propafenone in the treatment of arrhythmia.It can take into account both the clinical efficacy and the safety of medications.It can help patients correct their arrhythmia problems,and can be given priority when excluding medication contraindications.