卡前列素氨丁三醇与宫缩素治疗产后出血的效果比较

Effect comparison of Carboprost Tromethamine and Oxytocin in the treatment of postpartum hemorrhage

目的研究分析卡前列素氨丁三醇与宫缩素治疗产后出血的效果。方法选取2015年2月~2016年12月在本院接受产后出血治疗的100例患者作为研究对象,按照随机数字表法将其分为观察组与对照组,每组各50例。观察组患者使用卡前列素氨丁三醇进行治疗,对照组患者使用宫缩素进行治疗。比较两组患者的治疗总有效率、不良反应发生率及凝血功能指标水平。结果观察组患者的治疗总有效率(96.00%)高于对照组(82.00%),差异有统计学意义(P<0.05)。治疗后,观察组患者的血小板、纤维蛋白原水平低于对照组,凝血酶原时间、凝血活酶时间短于对照组,差异有统计学意义(P<0.05)。观察组患者的不良反应总发生率(4.00%)低于对照组(18.00%),差异有统计学意义(P<0.05)。结论在临床治疗中,使用卡前列素氨丁三醇治疗产后出血具有极高的使用价值,其疗效理想,不仅能显著降低凝血因子水平,还可预防不良反应的发生,此药值得在各大基层医院的临床治疗中大力推广。

Objective To study and analyze the effect of Carboprost Tromethamine and Oxytocin in the treatment of postpartum hemorrhage.Methods A total of 100 patients undergone postpartum hemorrhage treatment in our hospital from February 2015 to December 2016 were selected as the study subjects,and were divided into observation group and control group according to the random number table method,50 cases in each group.In the observation group,Carboprost Tromethamine was adopted,and in the control group,Oxytocin was used.The total effectiveness rate,incidence of adverse reactions and levels of coagulation function indicators were compared between the two groups.Results The total effectiveness rate in the observation group was 96.00%,which was higher than that in the control group accounting for82.00% with a statistical difference（P〈0.05）.After treatment,the platelet and fibrinogen levels in the observation group were lower than those in the control group,and the prothrombin time and thrombo plastin time were shorter than those in the control group,which were displayed statistically significant（P〈0.05）.The total incidence of adverse reactions in the observation group was 4.00%,which was much lower than that of the control group accounting for 18.00% with statistical significance（P〈0.05）.Conclusion In the clinical treatment of postpartum hemorrhage,the use of Carboprost Tromethamine has a very high value with a favorable effect.It not only reduces the coagulation factors significantly,but also prevents the occurrence of adverse reactions,which is worthy of wide promotion in major grass-roots hospitals.