胃黏膜癌变过程中叶酸对G-17和PG的影响

Effect of folic acid on G-17 and PG during gastric mucosal carcinogenesis

目的探讨胃黏膜癌变过程中叶酸对胃泌素-17(G-17)和胃蛋白酶原(PG)的影响。方法选择本院收治的240例慢性萎缩性胃炎患者与240例低级别上皮内瘤样变患者,将不同类别疾病患者随机分为对照组和观察组,每组120例。对照组实施常规治疗,观察组在对照组的基础上实施叶酸治疗。分析比较两组患者的治疗效果。结果观察组慢性萎缩性胃炎及其伴肠化生、Hp阳性患者的治疗有效率均显著高于对照组(P<0.05)。观察组低级别上皮内瘤样变及其伴肠化生、Hp阳性患者的治疗有效率均显著高于对照组(P<0.05)。结论叶酸可以通过影响G-17和PG水平来抑制胃黏膜癌变进程,值得在临床上推广和应用。

Objective To investigate the effects of folic acid on gastrin-17（G-17） and pepsinogen（PG） during gastric mucosal carcinogenesis. Methods A total of 240 patients with chronic atrophic gastritis and 240 cases of low grade intraepithelial neoplasia in our hospital were selected. The patients of different types of diseases were randomly divided into control group and observation group, with 120 cases in each group. The control group received routine treatment,while the observation group was treated with folic acid on the basis of the control group. The effects of treatment in the two groups were compared. Results The effective rates of treatment of patients with chronic atrophic gastritis, which combined with intestinal metaplasia and Hp positive patients in the observation group were significantly higher than those in the control group（P0.05）. The effective rates of treatment of patients with low grade intraepithelial neoplasia, which combined with intestinal metaplasia and Hp positive patients in the observation group were significantly higher than those in the control group（P 0.05）. Conclusion Folic acid can inhibit the carcinogenesis of gastric mucosa by affecting the levels of G-17 and PG, which is worth promoting and applying in clinic.