丹参川芎嗪注射液对急性颅脑损伤患者神经功能及炎症因子水平的影响

Effect of Danshen Chuanxiongqin injection on neurological function and inflammatory factors in patients with acute brain injury

目的探讨丹参川芎嗪注射液对急性颅脑损伤患者神经功能及炎症因子水平的影响。方法选取我院142例急性颅脑损伤患者为研究对象,随机分为对照组和研究组,每组71例。对照组给予常规治疗,研究组在对照组的基础上联合丹参川芎嗪注射液治疗。比较两组患者的临床效果。结果治疗后,两组NIHSS、ADL、MMSE评分、IL-6、IL-8及TNF-α水平较治疗前明显改善,且研究组明显优于对照组(P<0.05)。两组组患者不良反应总发生率比较,差异无统计学意义(P>0.05)。结论丹参川芎嗪注射液可有效促进患者的神经功能、认知功能及生活自理能力,抑制机体炎症反应,且不增加不良反应,值得在急性颅脑损伤治疗中应用推广。

Objective To explore the effect of Danshen Chuanxiongqin injection on neurological function and inflammatory factors in patients with acute brain injury. Methods A total of 142 patients with acute brain injury were selected and randomly divided into control group and study group, with 71 cases in each group. The control group was treated with conventional treatment, and the study group was given Danshen Chuanxiongqin injection based on the control group. The clinical effects were compared between the two groups. Results After treatment, the scores of NIHSS, ADL and MMSE, levels of IL-6, IL-8 and TNF-α improved in the two groups, and those in the study group were better than the control group（P0.05）. There was no significant difference in total incidence of adverse reactions between the two groups（P0.05）. Conclusion Danshen Chuanxiongqin injection in the treatment of acute brain injury can effectively promote the recovery of neurological function, cognitive function and self-care ability, inhibit the body＇s inflammatory response, and do not increase adverse reactions, which is worthy of application promotion in patients with acute brain injury.