不同辅助性化疗对早期乳腺癌术后康复效果的影响

Effect of different adjuvant chemotherapy on postoperative rehabilitation of early breast cancer

目的研究不同辅助性化疗对早期乳腺癌术后康复效果的影响。方法将我院收治的128例采用保乳术治疗的早期乳腺癌患者随机分为对照组和观察组,各64例。两组手术方法相同,对照组化疗方案选择AC化疗方案(阿霉素联合环磷酰胺),观察组采用新型辅助化疗TC方案(多西紫杉醇联合环磷酰胺)。比较两组患者的康复效果。结果近期疗效比较,观察组的总有效率为87.50%,显著高于对照组的73.44%(P<0.05);两组患者的各项不良反应发生率、局部复发率、腋淋巴结复发率、远处转移率及5年总生存率比较,差异无统计学意义(P>0.05)。观察组的5年无病生存率显著高于对照组(P<0.05)。结论多西紫杉醇联合环磷酰胺可以作为一种良好的化疗方案应用于早期乳腺癌术后治疗中,以多西紫杉醇为基础的其他化疗方案需要进一步研究。

Objective To study the effect of different adjuvant chemotherapy on postoperative rehabilitation of early breast cancer. Methods A total of 128 breast cancer patients who treated with breast-conserving surgery were randomly divided into control group and observation group, with 64 cases in each group. All the patients received the same surgical procedure. The control group was given AC chemotherapy regimen（adriamycin combined with cyclophosphamide）, and the observation group was treated with TC chemotherapy regimen（docetaxel combined with cyclophosphamide）. The rehabilitation effects of the two groups were compared. Results In the comparison of short-term clinical efficacy, the total effective rate of the observation group was 87.50%, which was higher than 73.44% of the control group（P0.05）. There were no significant differences in the incidence rates of adverse reactions, local recurrence rate, axillary lymph node recurrence rate, distant metastasis rate and 5 years overall survival rate between the two groups（P 0.05）. The 5-year disease-free survival rate of the observation group was significantly higher than that of the control group（P 0.05）.Conclusion Docetaxel combined with cyclophosphamide can be used as a good chemotherapy regimen in the clinical practice of early breast cancer, and docetaxel-based chemotherapy regimens requires further study.