24h尿总蛋白和尿微量白蛋白联合检测对2型糖尿病早期肾损伤的诊断价值

Value of Combined Detection of 24-hour Urinary Total Protein and Urinary Microalbumin for Diagnosis of Early Renal Injury in Type 2 Diabetes

目的探讨24h尿总蛋白和尿微量白蛋白联合检测对2型糖尿病早期肾损伤的诊断价值。方法选择90例2型糖尿病患者作为研究组[根据空腹血糖(FPG)水平将90例2型糖尿病患者分为轻度组(FPG<7 mmol·L^(-1),n=29)、中度组(7mmol·L^(-1)≤FPG≤9mmol·L^(-1),n=31)和重度组(FPG>9mmol·L^(-1),n=30)],另选择30例健康体检者作为对照组,分别检测血清FPG及24h尿总蛋白、尿微量白蛋白的水平,并比较其水平的差异和检测的阳性率。结果轻度组、中度组、重度组血清FPG及24h尿总蛋白、尿微量白蛋白水平均明显高于对照组(均P<0.05),且随着病情程度的加重,血清FPG及24h尿总蛋白、尿微量白蛋白水平均明显升高(均P<0.05)。研究组血清FPG、24h尿总蛋白及尿微量白蛋白检测阳性率均明显高于对照组(均P<0.05)。结论 24h尿总蛋白和尿微量白蛋白联合检测可作为2型糖尿病早期肾损伤诊断的参考依据,便于临床及早制定治疗措施。

Objective To explore the value of combined detection of 24-hour urinary total protein and urinary microalbumin for diagnosis of early renal injury in type 2 diabetes.Methods According to fasting plasma glucose（FPG）levels,90 patients with type 2 diabetes（study group）were further divided into mild group（FPG〈7 mmol·L^（-1）,n=29）,moderate group（7 mmol·L^（-1）≤FPG≤9 mmol·L^（-1）,n=31）and severe group（FPG〉9 mmol·L^（-1）,n=30）.In addition,30 healthy subjects were selected as the control group.Serum FPG,24-hour urinary total protein and urinary microalbumin levels were detected,and the positive rate of detection was measured.Results The levels of serum FPG,24-hour urinary total protein and urinary microalbumin in mild group,moderate group and severe group were significantly higher than those in control group（P〈0.05）.Furthermore,serum FPG,24-hour urinary total protein and urinary microalbumin levels increased with the severity of the disease（P〈0.05）.The serum FPG,24-hour urinary total protein and urinary microalbumin positive detection rates in study group were significantly higher than those in control group（P〈0.05）.Conclusion The combined detection of 24-hour urinary total protein and urinary microalbumin can be used as a reference for early diagnosis of renal injury and the development of treatment measures in patients with type 2 diabetes.