摘要
3D打印技术是一种通过计算机辅助设计及控制制备具有特殊外形和复杂内部结构物体的快速成形技术。该技术具有加工灵活、成形快、可靠性高和费用低等诸多优势,为新型给药系统的研究提供了新策略与新途径,在制剂设计中得到了越来越多的关注。本文综述了制剂研究中涉及的3D打印技术及其特点,重点介绍了3D打印技术在实现控速释药、定时释药及靶向释药等方面的相关制剂设计研究进展,展望了3D打印技术在制剂工程化应用中的前景与挑战。
Three-dimensional(3 D) printing technology is a rapid prototyping technology for designing 3 D models with special shape and complex internal structure via computer-aided/controlled drawing and preparing.This technology displays the characteristics of flexible processing,rapid shaping,low operating cost and high reliability.3 D printing technology may provide new strategies and approaches for the generation of a variety of new drug delivery systems,which makes its application in pharmaceutics attractive.This review briefly introduces the process and feature of 3 D printing technology in preparation field and mainly introduces the research progress in the design and engineering of related preparations in the aspects of rate-controlled drug release,time-controlled drug release and targeted drug release.The prospects and challenges of 3 D printing technology in the formulation engineering are analyzed.
作者
赵炯
姜孟劳
丁杨
ZHAO Jiong;JIANG Meng-lao;DING Yang(State Key Laboratory of Natural Medicines,School of Pharmacy,China Pharmaceutical University,Nanjing 210009,China)
出处
《药学学报》
CAS
CSCD
北大核心
2018年第8期1302-1309,共8页
Acta Pharmaceutica Sinica
基金
国家科技重大专项基金资助项目(2017ZX09101001006022)
国家自然科学基金资助项目(81501582)
江苏省自然科学基金资助项目(BK20171390)
关键词
3D打印技术
控速释药
定时释药
靶向释药
3D printing technology
rate-controlled drug release
time-controlled drug release
targeted drugrelease