益气解毒法治疗普通感冒(气虚邪犯证)的疗效观察及对细胞因子HβD-2的影响

Clinical efficacy of the treatment of common cold(syndrome of Qi deficiency and evil invasion) and the influence on cytokine HβD-2 by tonifying Qi and detoxification

目的:观察益气解毒法治疗普通感冒(气虚邪犯证)的临床疗效。方法:采用随机对照的方法,把40例普通感冒患者(气虚邪犯证)随机分为试验组20例,对照组20例。试验组采用感毒清颗粒加减配伍(咽痛甚加牛蒡子、板蓝根,表症明显加金银花、连翘,咳嗽甚加桔梗、苦杏仁)口服,每日3次。对照组采用复方氨酚烷胺胶囊,每天2次。3d1个疗程后对比临床治疗疗效及对人β-防御素-2(HβD-2)的变化情况。结果:完成观察的合格病例试验组19例,对照组19例。试验组的总有效率为100%、愈显率为42.1%,对照组的总有效率为94.7%、愈显率为31.5%,两组愈显率比较差异无统计学意义(P>0.05)。两组治疗后咽部症状、体征积分均较治疗前改善(P<0.05),但试验组效果优于对照组。试验组与对照组HβD-2水平治疗前、后及组间对照差异无统计学意义(P>0.05),试验组3天前后差值与对照组相比差异有统计学意义(P=0.05)。在用药过程中,试验组未发现明显不良事件;对照组出现不良事件6例,表现为头昏、嗜睡,不良事件发生率为31.58%。结论:益气解毒法能够改善普通感冒(气虚邪犯证)的各种症状,尤其是较好地缓解咽痛症状达到治疗普通感冒的目的。

Objective： To observe the clinical efficacy of treating common cold（syndrome of Qi deficiency and evil invasion） by tonifying Qi and detoxification. Method： 40 common cold patients manifested as Qi deficiency and evil invasion syndrome were randomly divided into treatment group（20 patients） and control group（20 patients）. The treatment group was treated with oral administration of modified Ganduqing granules（patients with obvious sore throat added Niubangzi and Banlangen, patients with typical exterior symptom added Jinyinhua and Lianqiao,patients with severe cough added Jiegeng and Kuxingren）, 3 times a day. The control group was treated with Compound Paracetamol and Amantadine Hydrochloride Capsule, 2 times a day. The clinical efficacy and the expression changes of human beta defense-2（HβD-2） were compared between the two groups after 3 days for a course. Result： Both the control group and the treatment group had 19 qualified cases of completed observation. Total effective rate was 100 % and cure rate was 42.1% in the treatment group. The total effective rate was 94.7 % and cure rate was up to 31.5% in the control group. The cure rates of two groups had no statistical significance（P〈0.05）. After treatment, pharyngeal symptom and symptoms integral were better in both groups（P〈0.05）. But the effect of the treatment group outdid that of the control group. The comparison of HβD-2 level had no statistical significance in the interior-group and inter-group before and after treatment（P〈0.05）. Compared with the control group, the difference of HβD-2 level before and after 3 days in the treatment group had statistical significance（P〈0.05）. During whole process of medication, no obvious adverse reaction was reported in the treatment group. However, 6 cases of adverse reaction was reported in the control group which manifested as dizziness or sleepiness with 31.58% incidence rate. Conclusion： Tonifying Qi and detoxification method can alleviate various symptoms of common cold（syndrome of Qi deficiency and evil invasion）, especially in the relief of sore throat, to achieve the therapeutic purposes of common cold.