喘息性支气管炎与小儿哮喘患者血清中IgE、LTs、MBP含量相关性分析

Correlations of IGE,LTs,MBP in Asthmatic Bronchitis and Asthma Children

目的:分析喘息性支气管炎患儿血清中免疫球蛋白E(Ig E)、髓鞘碱性蛋白(MBP)、白三烯(LTs)含量与哮喘的相关性。方法:选取2015年9月-2017年2月在本院住院的喘息性支气管炎患儿108例,均进行退热、止咳、平喘治疗,经1年随访,脱落8例,最终纳入100例患儿。根据最终是否发展为哮喘将其分为研究组33例(最终发展为哮喘)和对照组67例(治疗后未发展为哮喘)。检测两组治疗前后血清Ig E、LTs、MBP含量;分析患儿血清LTs、MBP、Ig E含量与哮喘的相关性。结果:治疗后,对照组血清Ig E、LTs、MBP含量均低于治疗前,研究组血清Ig E、LTs、MBP含量均高于治疗前,比较差异均有统计学意义(P<0.05);治疗前后,研究组血清Ig E、LTs、MBP含量均高于对照组,比较差异均有统计学意义(P<0.05);单因素及多因素分析显示Ig E、LTs、MBP均是哮喘发作的影响因素(P<0.05)。结论:通过Ig E、LTs、MBP水平可以初步评价喘息性支气管炎患儿预后及发展为哮喘,为喘息性支气管炎及哮喘的治疗、预防、诊断及预后评价提供新的临床指标和研究基础。

Objective：To analyzed the correlation between serum IGE,LTs,MBP and asthma in children with asthmatic bronchitis. Method：A total of 108 children with asthmatic bronchitis admitted to our hospital from September 2015 to February 2017 were selected,all patients were treated with antipyretic,cough relieving and antiasthmatic treatment. After 1 year of follow-up,8 cases were dropped out,and 100 children were eventually enrolled.According to whether asthma was developed in the final stage,they were divided into 33 cases of study group（eventually developing asthma） and 67 cases in control group（did not develop asthma after treatment）.The serum levels of Ig E,LTs and MBP were measured before and after treatment in two groups,the correlation between serum LTs,MBP and Ig E levels and asthma was analyzed. Result：After treatment,the serum levels of Ig E,LTs and MBP in control group were all lower than those of before treatment,the serum levels of Ig E,LTs and MBP in study group were all higher than those of before treatment,the differences were statistically significant（P〈0.05）. Before and after treatment,the serum levels of Ig E,LTs and MBP in study group were higher than those of control group,the differences were statistically significant（P〈0.05）. Univariate and multivariate analysis showed that Ig E,LTs and MBP were all risk factors for asthma attack（P〈0.05）. Conclusion：Through the Ig E,LTs,MBP level can be a preliminary evaluation of the prognosis of children with asthmatic bronchitis and for the development of asthma,for asthmatic bronchitis and asthma treatment,prevention,diagnosis and prognosis evaluation provide the new clinical index and research base.