米非司酮联合雷公藤多苷治疗子宫肌瘤的临床疗效观察

The Clinical Efficacy of Mifepristone Combined with Tripterygium Glycosides for Uterine Fibroids

目的探讨米非司酮联合雷公藤多苷治疗子宫肌瘤的疗效及其对血清NOS、TNF-α、IL-2水平的影响。方法将82例子宫肌瘤患者,按照奇偶数字法均分为对照组(n=41)与观察组(n=41)。对照组仅采用米非司酮治疗,观察组在此基础上联合雷公藤多苷治疗。比较两组临床疗效、患者治疗前后血清NOS、TNF-α及IL-2水平、治疗后随访及不良反应发生情况。结果 (1)经治疗,观察组临床总有效率为95.12%(39/41),显著高于对照组(75.61%,31/41)(P<0.05);(2)两组患者治疗后血清NOS及TNF-α水平均显著低于治疗前(P<0.05),治疗后血清IL-2水平均显著高于治疗前(P<0.05);观察组患者治疗后血清NOS及TNF-α水平均显著低于对照组患者治疗后,IL-2水平显著高于对照组患者治疗后,差异均具有统计学意义(P<0.05);(3)两组患者随访时间差别不大(P>0.05),观察组肌瘤复发率及月经不正常发生率均显著低于对照组(P<0.05)。结论米非司酮联合雷公藤多苷治疗子宫肌瘤的疗效显著,应在临床上进行推广。

Objective To evaluate the clinical efficacy of mifepristone combined with tripterygium glycosides for uterine fibroids and its effects on serum NOS,TNF-α,IL-2 levels. Methods 82 patients with uterine fibroids were divided into 2 groups randomly. The control group（ n = 41） received mifepristone,The observation group（ n = 41） received mifepristone combined with tripterygium glycosides. The clinical efficacy and the level of NOS,TNF-α,IL-2 were compared between the 2 groups. Results After treatment,the total effective rate in the observation group was 95. 12%（ 39/41）,which was significant higher than control group（ 75. 61%,31/41）（ P 〈 0. 05）;（2） The level of NOS and TNF-α were significantly lower than before treatment（ P 〈 0. 05）in the 2 groups,however,the IL-2 of both groups was opposite. Meanwhile,after treatment,the level of NOS and TNF-αin observation group were significantly lower than control group（ P 〈 0. 05）,the level of IL-2 in the observation group were significantly higher than the control group（ P 〈 0. 05）;（3） The recurrence rate of fibroids menstruation in the observation group was significantly lower than the control group（ P 〈 0. 05）. Conclusion Tripterygium glycosides combined with mifepristone is effective for uterine fibroids,it is worthy of clinical practice.