丙酸氟替卡松治疗儿童过敏性鼻炎的效果分析

Efficacy of fluticasone propionate in the treatment of children with allergic rhinitis

目的探讨丙酸氟替卡松治疗儿童过敏性鼻炎的效果及机制。方法选择2015年3月至2016年3月该院接诊的儿童过敏性鼻炎患儿120例为研究对象,随机将其分为观察组和对照组,每组60例。观察组的患儿采用丙酸氟替卡松气雾剂治疗,对照组的患儿采用酮替芬治疗。观察两组患儿的治疗效果以及治疗前后骨桥蛋白、白细胞介素(IL)-4、IL-5水平,并比较不良反应发生情况。结果经研究发现,观察组有效率93.3%,与对照组(85.0%)相比,差异有统计学意义(P<0.05)。观察组骨桥蛋白、IL-4、IL-5的水平在丙酸氟替卡松气雾剂治疗前后比较,差异有统计学意义(P<0.05)。观察组和对照组的不良反应发生率分别为5.0%和6.7%,差异无统计学意义(P>0.05)。结论丙酸氟替卡松可以改善过敏性鼻炎患儿的症状,治疗效果较好,能明显提高患儿的生活质量,值得进一步研究应用。

Objective To investigate the effects of fluticasone propionate and inflammatory mechanism of children with allergic rhinitis.Methods A total of 120 children with allergic rhinitis in our hospital from March 2015 to March 2016 were selected and randomly divided into observation group and control group.Children in the observation group were treated with fluticasone propionate aerosol,and children in the control group were treated with ketotifen.The therapeutic effect of the two groups of patients and the levels of osteopontin,IL-4 and IL-5 before and after treatment were observed.And the incidences of adverse reactions were compared.Results The study found that the effective rates of observation group and control group were93.3% and 85.0%,the difference was statistically significant（P〈0.05）.After treatment,the levels of osteopontin,IL-4 and IL-5 in the observation group were significantly lower than before（P〈0.05）.The incidences of adverse reactions in the observation group and the control group were 5.0%and 6.7%,respectively,and there was no significant difference between the two groups（P〈0.05）.Conclusion Fluticasone propionate could improve the symptom of children with allergic rhinitis,and has a better effect,as well as improve the quality of life of children.It is worthy of deeper research.