DHCR24表达的调控及其与丙型肝炎病毒感染的研究进展

Regulation of DHCR24 expression and its progress with HCV infection

24-脱氢胆固醇还原酶（3β-hydroxysterolΔ~24-reductase,DHCR24）可催化链甾醇转化为胆固醇,参与多种脂代谢异常相关疾病（肝病、心血管疾病和链甾醇血症等）的发生发展。丙型肝炎病毒（hepatitis C virus,HCV）感染导致肝脏脂代谢紊乱以及肝脏炎症,并且可通过增强子诱导DHCR24表达增多[1-2]。

3β-hydroxysterol Δ^（24）-reductase（ DHCR24） catalyzes the conversion of desmosterol to cholesterol and in turn affects lipid metabolism. DHCR24 is a multifunctional protein with enzymatic activity, antioxidant stress,scavenging of reactive oxygen species（ ROS） and anti-apoptotic effects. Hepatitis C virus（ HCV） infection results in severe oxidative stress which is correlated closely with fatty liver,liver cirrhosis,liver cancer and a series of liver diseases.Recent studies have shown that DHCR24 expression is regulated by various factors such as sterols,hormones and growth factors,and the expression of DHCR24 is significantly increased after HCV infection. In-depth study of the function and regulation of DHCR24 and its relationship with disease can be help to further discover and understand the pathogenesis,and contribute to early diagnosis and treatment of disease. This review summarizes the regulation of DHCR24 expression and its progress with HCV infection.