瞬时受体电位通道在细胞自噬中的调控作用

Regulation Role of Transient Receptor Potential Channel in Autophagy

自噬是机体在应对外界低氧、营养缺乏、炎症、癌症发生等胁迫条件下,将目标物质运送到溶酶体进行降解,并将转化的物质重新利用,以维持细胞生存的细胞过程。瞬时受体电位(TRP)通道超家族是目前最大的阳离子通道家族之一,多具Ca^(2+)通透性,发挥着疼痛、味觉等感觉信号传递及调节细胞钙平衡和影响发育等功能。在受到不利于生存的刺激时,机体会通过调节TRP通道来调节自噬。因此,未来需进一步研究TRP通道调控细胞自噬的信号通路,以为寻找治疗人类疾病的治疗靶点提供理论依据。

Autophagy is a cellular process responsible for the delivery of proteins or organelles to lysosomes for its degradation under the conditions of external hypoxia,nutritional deficiency,inflammation,cancer and other stress. Transient receptor potential（TRP） channel with the Ca2 ＋permeability is one of the largest families of cation channels discovered so far,which plays a role in the signal transduction of pain,taste and other senses,regulating the intracellular calcium balance and influencing the growth. A number of studies have shown that the organism regulates autophagy by TRP channel in response to the stimuli that is not conducive to survival. Therefore,further study on the signaling pathway of TRP channel in regulating autophagy is needed in the future,so as to provide a theoretical basis for finding therapeutic targets for treating human diseases.