骨膜蛋白在呼吸系统疾病中的作用

Role of Periostin in Respiratory Diseases

骨膜蛋白参与许多疾病的病理生理学过程,通过调节下游基因的表达调节细胞间的相关作用。呼吸系统疾病最常见的特征是上皮细胞损伤以及炎症导致的骨膜蛋白等分泌增加。骨膜蛋白随后参与到气道重构及肺病理生理学的其他方面。在支气管哮喘中,骨膜蛋白作为新型生物标志物,可作为支气管哮喘急性加重和肺功能下降等的预测因子,也可作为嗜酸粒细胞性气道炎症的生物标志物。骨膜蛋白在特发性肺纤维化中的高表达也可以作为临床进展的指征。

Periostin is involved in the pathophysiological processes of many diseases and regulates the intercellular related effects by regulating the expression of downstream genes. The most common features of respiratory disease are epithelial cell damage and increased secretion of periosteum protein caused by inflammation. Periostin then participates in airway remodeling and other aspects of lung pathophysiology. In bronchial asthma,periostin as a novel biomarker of inflammation can be used as a predictor of lung exacerbation and decreased lung function,and as a systemic biomarker of eosinophilic airway inflammation. The high expression of periostin in idiopathic pulmonary fibrosis can also serve as an indication of the clinical progression.