基于隐形眼镜眼科给药的研究进展

Advances in the Study of Ophthalmic Administration of Contact Lenses

近年来,眼用给药系统已经成为医药市场研究和开发的热点。对于眼用制剂来说,增加药物与角膜的接触时间是提高药效的重要因素。与传统眼部药物递送剂型相比,隐形眼镜(CLs)眼科给药可以将药物直接递送到角膜上,减少药物的系统损失,提高生物利用度。更有一些新型材料和技术使CLs在眼部药物递送上达到缓控释效果,减少给药次数,同时也可消除患者经连续给药给眼部带来的刺激和不适。CLs给药系统虽然还有一些问题有待解决,但却是一个很有发展潜力的给药系统。

In recent years,ophthalmic drug delivery systems have become a hot topic in the research and development of the pharmaceutical market. For ophthalmic preparations,increasing the contact time of the drug with the cornea is an important factor in improving the efficacy. Compared with traditional ophthalmic drug delivery forms,ophthalmic administration of contact lenses（CLs） can deliver drugs directly to the cornea,reducing systemic loss of the drug and increasing bioavai-lability. In addition,some new materials and technologies have enabled CLs to achieve sustained-release effects on drug delivery to the eye,reducing the number of administration,thus eliminating the irritation and discomfort caused by continuous administration to the eye. Although there are still some problems to be solved in the CLs drug delivery system,it is of great potential for development.