基于痰瘀互结理论探讨特发性膜性肾病的中医病机及治疗

TCM Pathogenesis and Treatment of Idiopathic Membranous Nephropathy Based on the Theory of Phlegm and Blood Stasis

特发性膜性肾病(IMN)是一类发病机制复杂、临床尚未明确病机的疾病,可诱发肾病综合征,后果严重。部分IMN采用免疫疗法或激素治疗无效,成为难治性IMN,严重者可引起肾衰竭,威胁患者的生命。IMN西医治疗效果一般,药物选择性差,不良反应较大。近年来临床研究显示,中医理论等传统医学手段在治疗IMN方面取得了一定进展,但相关研究较少,也缺乏系统的中医病机整理,临床也尚无统一标准。因此,探讨分析IMN的中医病机,是临床中医防治IMN的重要方向。

Idiopathic membranous nephropathy（IMN） is a class of diseases with complex and unclear pathogenesis.It can induce nephrotic syndrome with serious consequences. Some IMNs treated with immunotherapy or hormone therapy achieve no curative effect,and become intractable IMN,which can cause kidney failure and threaten the lives of patients in serious cases. Western medicine treatment effect of IMN is not ideal,with poor drug selectivity and great adverse effects.Clinical studies in recent years have shown that traditional medicine methods such as traditional Chinese medicine（TCM）theory have made progress in the treatment of IMN,but there are few related studies,a lack of systematic TCM pathogenesis study,and there is no uniform clinical standard. Therefore,to explore and analyze the TCM pathogenesis of IMN is an important direction for the clinical TCM prevention and treatment of IMN.