摘要
研究C_(70)富勒醇(简写为C_(70)-OH)在常规治疗剂量下对小鼠心脏功能的影响。通过对小鼠行为学的观察和对心脏系数、血生化指标、心脏组织病理学和组织透射等的检测,结果显示常用的小分子血管阻断剂康普瑞汀磷酸二钠(CA4P)对心肌有明显损伤,而C_(70)-OH未表现出明显的心脏毒性。
The cardiac effect of C70 fullerenol nanoparticles（C70-OH NPs）was studied in mice.After treated with the C70-OH fullerene of normal therapeutic dose,behavioral observation,cardiac coefficient,blood biochemical changes,pathological changes and tissue transmission of mice were detected.The results showed that the commonly used small molecule vascular blocker combretastatin disodium phosphate（CA4 P）significantly damaged the myocardium,while C70-OH did not show significant cardiotoxicity.
作者
郭君
周悦
杨冬芝
甄明明
许辉
王春儒
GUO Jun;ZHOU Yue;YANG Dongzhi;ZHEN Mingming;XU Hui;WANG Chunru(Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy,Xuzhou Medical University,Xuzhou 221004,Jiangsu,P.R.China;Key Laboratory of Molecular Nanostructure and Nanotechnology,Institute of Chemistry,Chinese Academy of Sciences,Beijing 100190,P.R.China;University of Chinese Academy of Sciences,Beljing 100049,P.R.China)
出处
《影像科学与光化学》
CAS
CSCD
2018年第4期324-330,共7页
Imaging Science and Photochemistry
基金
国家重大科研装备项目(ZDYZ2015-2)资助
关键词
C70富勒醇
病理学变化
组织透射
心脏毒性
C70 fullerenol
pathological changes
tissue transmission
cardiac toxicity
