表观遗传学在肺动脉高压发病机制和治疗中的研究进展

Research progress of epigenetic in pathophysiology and therapeutics of pulmonary hypertension

表观遗传学是研究在DNA序列没有改变的情况下,基因功能可逆的、可遗传改变的一门生物学学科。表观遗传学与众多复杂性疾病的发生、发展密切相关,同样与肺动脉高压的发生、发展相关。该文主要对部分表观遗传成分和基因DNA甲基化和组蛋白修饰在肺动脉高压发生、发展中的作用,DNA甲基化转移酶抑制剂、组蛋白去乙酰化酶抑制剂及其他潜在治疗靶点对肺动脉高压的治疗作用及机制进行了综述。

Epigenetics,as the latest biological science in recent years,refers to the changes and reversible gene function in phenotype and gene expression without alterations in DNA sequence. Epigenetics is associated with the occurrence and development of sorts of complex disorders,which can be applied to pulmonary hypertension. In this review,we summarize the basics of two types of epigenetic modification mediated by DNA methylation,the post-translational modifications of histone tails and the known sites and molecules involved in pulmonary hypertension,as well as the inhibitor of histone deacetylas,inhibitor of DNA methyltransferase and the underlying therapy mechanisms.