不同时间口服二甲硅油对结肠镜检查效果的影响

Effects of taking oral Dimethicone at different times on colonoscopy

目的探究患者在不同时间口服二甲硅油对结肠镜检查效果的影响。方法选取2016年12月至2017年7月在安徽医科大学第三附属医院消化内科行结肠镜检查的800例患者为研究对象,按随机数表法将其平均分为A、B、C和D组。在结肠镜检查前6 h,A组患者口服复方聚乙二醇散;其余3组分别在A组的基础上,于检查前4、2和6 h服用二甲硅油。比较4组患者肠镜检查时肠道清洁度、肠道内气泡含量、耐受度及药物不良反应。结果肠道内气泡含量:B组显著少于其他三组(P<0.05),C组显著少于A、D两组(P<0.05),A与D组之间差异无统计学意义(P>0.05)。耐受度:B组显著高于其他三组(P<0.05),C组显著高于A、D组(P<0.05),A与D组之间差异无统计学意义(P>0.05)。四组患者肠道清洁度Boston评分和对药物不良反应方面相比,差异均无统计学意义(P>0.05)。结论在结肠镜检查前4 h服用二甲硅油,能更有效地减少患者肠道内的气泡,并显著提高患者对结肠镜检查的耐受度。

Objective To investigate the effects of oral Dimethicone on patients before colonoscopy at different times. Methods Eight hundred patients who received common colonoscopy in the Third Affiliated Hospital of Anhui Medical University from Dec. 2016 to Jul. 2017 were collected,they were randomly divided into groups A,B,C and D. The group A was given oral compound polyethylene glycol electrolyte powder 6 hours before the colonoscopy. The remaining three groups were on the basis of group A and were given Dimethicone 4,2 and 6 hours before the operation respectively. The endoscopic mucosal visibility,intracolic foam,tolerance degree and adverse reactions of medications were compared. Results The amount of intracolic foam： group B was significantly less than the other three groups（ P〈0. 05）,group C was significantly less than group D and group A（ P〈0. 05）,there was no statistical difference between group A and group D（ P〉0. 05）. The tolerance degree： group B was significantly higher than the other three groups（ P〈0. 05）. Group C was significantly higher than group D and group A（ P〈0. 05）,there was no statistical difference between group D and group A（ P〉0. 05）. The bowel cleanliness of the Boston score and the patients＇ adverse reactions of medications had no statistical difference among four groups（ P〉0. 05）. Conclusion Oral administration of Dimethicone can reduce the intracolic foam and improve the tolerance degree more effective at 4 hours before colonoscopy.