阿托伐他汀钙治疗冠心病的效果及对患者血清炎症因子、氧化应激指标的影响

Effect of atorvastatin calcium on coronary heart disease and its influence on serum inflammatory factors and oxidative stress indexes

目的探讨冠心病患者实施阿托伐他汀钙治疗的效果及对患者血清炎症因子、氧化应激指标的影响。方法选择本科室冠心病患者120例,根据随机数表将患者分为传统组(n=60,传统方案)与干预组(n=60,传统方案+阿托伐他汀钙),比较两组治疗效果。结果干预组患者的治疗总有效率为96.7%,高于传统组的80.0%(P<0.05),治疗后,两组患者的TFN-α、CRP、MDA水平均下降,SOD水平升高,且干预组均优于传统组(P<0.05)。结论冠心病患者实施阿托伐他汀钙治疗的疗效显著,且可改善患者血清炎症因子、氧化应激指标。

Objective To investigate the effect of atorvastatin calcium in patients with coronary heart disease and its effect on serum inflammatory factors and oxidative stress indexes. Methods A total of 120 patients with coronary heart disease in our department were selected. Patients were divided into traditional group（n=60, traditional regimen） and intervention group（n=60, traditional regimen combined with atorvastatin calcium） according to the random number table method.The efficacy of the two groups were compared. Results The total effective rate of treatment in the intervention group was96.7%, which was significantly higher than 80.0% of the traditional group（P〈0.05）. After treatment, the levels of TFN-α,CRP and MDA in the two groups dicreased, and the level of SOD increased, and those in the intervention group were better than the traditional group（P〈0.05）. Conclusion The atorvastatin calcium in patients with coronary heart disease has significant effect, and it can improve serum inflammatory factors and oxidative stress.