不同剂量雌激素应用于宫腔粘连术后患者的效果及复发情况

Effect and recurrence of different doses of estrogen in patients with postoperative intrauterine adhesions

目的分析不同剂量雌激素在宫腔粘连术后患者中的应用效果及复发情况。方法选我院收治的宫腔粘连患者96例,随机分为观察组(n=46)和对照组(n=50)。所有患者均接受宫腔镜下粘连分离术,观察组术后给予9 mg雌激素治疗,对照组给予3 mg雌激素治疗。观察比较两组的治疗效果、子宫内膜厚度、月经恢复情况、粘连复发率及不良反应总发生率。结果与对照组比较,观察组总有效率更高,月经恢复正常率更高,粘连复发率更低(P<0.05);治疗后,两组患者的子宫体积和子宫内膜厚度均明显优于治疗前,且观察组优于对照组(P<0.05)。两组患者的不良反应总发生率比较,差异无统计学意义(P>0.05)。结论较高剂量雌激素用于治疗宫腔镜术后粘连的临床效果优于低剂量雌激素治疗,能够有效预防粘连复发且不良反应少。

Objective To analyze the application effect and recurrence of different doses of estrogen in patients with postoperative intrauterine adhesions. Methods A total of 96 patients with intrauterine adhesions in our hospital were randomly divided into observation group（n=46） and control group（n=50）. All the patients underwent resection of intrauter-ine adhesions. The observation group was given 9 mg estrogen after operation, and the control group was given 3 mg after operation. The treatment effect, endometrial thickness, menstrual recovery, adhesion recurrence rate and the total inci-dence of adverse reactions in the two groups were observed and compared. Results Compared with the control group,there was higher total effective rate, higher menstrual recovery rate and lower adhesion recurrence rate in the observation group（P〈0.05）. After treatment, the uterine volume and endometrium thickness of the two groups were better than those before treatment, and those in the observation group were better than the control group（ P〈0.05）. There was no significant difference in the incidence of adverse reactions between the two groups（P〈0.05）. Conclusion The higher dose of estrogen for patients with postoperative intrauterine adhesions has better clinical effect than low dose of estrogen therapy,which can effectively prevent the recurrence of adhesions, with fewer adverse reactions.