C反应蛋白及降钙素原在评估急性胰腺炎危重度中的临床价值

Clinical values of C-reactive protein and proealcitonin in assessing the severity of acute pancreatitis

目的探讨C反应蛋白(CRP)及降钙素原(PCT)对于评估急性胰腺炎严重程度的临床价值。方法收集我院急性胰腺炎患者共81例,根据病情轻重程度将其分为轻型胰腺炎组(MAP组,33例)和重症胰腺炎组(SAP组,48例),测定两组血清CPR及PCT的水平。结果 SAP组入院24 h内的血清CRP和PCT水平均显著高于MAP组(P<0.05)。CRP联合PCT诊断急性胰腺炎严重程度的灵敏度及准确度高于CRP、PCT单独诊断。结论急性胰腺炎能明显引起CRP及PCT的反应,早期测定两者的水平有助于病情严重程度的评估及诊断。

Objective To explore the clinical values of C-reactive protein（CRP） and procalcitonin（PCT） in the diagnosis of the severity of acute pancreatitis. Methods Eighty-one acute pancreatitis patients in our hospital were collected and divided into mild acute pancreatitis group（MAP group, n=33） and severe acute pancreatitis group（SAP group, n=48） according to severity of illness. The serum levels of CRP and PCT in the two groups were measured within 24 h after admission. Results The serum levels of CRP and PCT in the SAP group were significantly higher than those in the MAP group within 24 h after admission（P〈0.05）. The sensitivity and accuracy of CRP combined with PCT in the diagnosis of the severity of acute pancreatitis were higher than those of CRP and PCT alone. Conclusion Acute pancreatitis can cause the CRP and PCT reaction obviously, and measured the serum levels of CRP and PCT at an early stage can help to assess the severity of acute pancreatitis.