TGAb或TPOAb抗体增高与甲状腺激素变化关系探究

The Relationship between the Increase of TGAb or TPOAb Antibody and the Change of Thyroid Hormone

目的调查某地区血清TGAb或TPOAb增高人群中甲状腺激素的改变情况。方法收集2013年1月—2015年12月首次检测血清TGAb或TPOAb增高样本,检测甲状腺激素水平并对数据进行统计分析。结果自身抗体增高样本中38.2%(1 372/3 590)的表现为FT3或FT4水平异常。2 090例样本TGAb和TPOAb两项抗体联合增高。FT3或FT4水平异常在TGAb和TPOAb两项抗体联合增高的样本中占45.0%(941/2 090)。17.2%(360/2 090)的样本表现为FT3和FT4结果正常,TSH结果异常(升高和降低)。结论 GAb和TPOAb的检测对甲状腺疾病(包括亚临床甲状腺疾病)的诊断有着重要的参考意义。

Objective This paper tries to investigate the changes of thyroid hormones in patients with elevated serum TGAb or TPOAb level in a certain area. Methods The serum TGAb or TPOAb increase samples were collected for the first time from January 2013 to December 2015. Thyroid hormone levels were measured and the data were statistically analyzed. Results 38.2%（1 372/3 590） of the autoantibodies showed abnormal FT3 or FT4 levels. In 2 090 cases, the TGAb and TPOAb two antibodies were combined. Abnormal levels of FT3 or FT4 accounted for 45.0%（941/2 090） of the combined increase in TGAb and TPOAb two antibodies. The 17.2%（360/2 090） sample showed normal FT3 and FT4 results and abnormal TSH results（increased and decreased）. Conclusion The detection of GAb and TPOAb has important reference significance for the diagnosis of thyroid diseases（including subclinical thyroid diseases）.