特利加压素与奥曲肽治疗肝硬化上消化道出血的效果对比

Comparison of the Effects of Terlipressin and Octreotide on Upper Gastrointestinal Bleeding in Cirrhosis

目的研究分析特利加压素与奥曲肽治疗肝硬化上消化道出血的临床应用效果。方法选取该院2015年4月—2017年6月接收的肝硬化上消化道出血患者68例,每组34例患者,均分两组予以治疗,对照组在常规对症治疗的基础上给予患者奥曲肽药物治疗,研究组则在该基础上使用特利加压素对患者进行治疗,对比两组的临床治疗效果后进行分析。结果研究组患者的尿量(1 252.46±238.17)m L、血肌酐(117.42±52.31)μmol/L以及平均动脉压(84.76±7.68)mm Hg指标改善均优于对照组,比较差异有统计学意义(t=6.881、4.328、2.735,P<0.05);研究组患者的治疗有效率为97.06%,高于对照组的70.59%,比较差异有统计学意义异(χ~2=8.785,P<0.05);研究组患者24 h内止血情况(29例)优于对照组(21例)、48 h在再出血率(2.94%)低于对照组(17.65%),组间比较差异有统计学意义(χ~2=4.836、3.981,P<0.05)。结论临床上,使用特利加压素、奥曲肽对肝硬化上消化道出血患者治疗的效果更加明显,可提高患者的临床治疗效果,值得推广应用。

Objective This paper tries to study the clinical efficacy of terlipressin and octreotide in the treatment of upper gastrointestinal bleeding in cirrhosis. Methods 68 patients with cirrhosis upper gastrointestinal hemorrhage received in this hospital from April 2015 to June 2017 were selected. 34 patients in each group. The control group was given octreotide drugs on the basis of routine symptomatic treatment. The study group on the basis of the use of terlipressin for the treatment of patients, compared the clinical efficacy of the two groups after analysis. Results The urine volume（1 252.46 ±238.17）m L, serum creatinine（117.42 ±52.31）μmol/L, and mean arterial pressure（84.76 ±7.68） mm Hg improved better in the study group than in the control group, with statistically significant differences（t= 6.881, 4.328,2.735,P〈0.05）; The effective rate of treatment in the study group was 97.06%, which was higher than that of the control group（70.59%）. There was a significant difference between the two groups（χ~2=8.785,P〈0.05）; The internal hemostasis（29 cases） was better than the control group（21 cases）, 48 hours in the rebleeding rate（2.94%） was lower than the control group（17.65%）, the statistical difference between the groups was significant（χ~2=4.836, 3.981,P〈0.05）. Conclusion Clinically, the use of terlipressin, octreotide for the treatment of upper gastrointestinal bleeding in patients with cirrhosis more effective, can improve the clinical treatment of patients, it is worth promoting.