甲氨蝶呤联合米非司酮保守治疗宫外孕的临床疗效分析

Clinical Efficacy of Methotrexate Combined with Mifepristone in the Treatment of Ectopic Pregnancy

目的探究甲氨蝶呤和米非司酮两药物合用于宫外孕保守治疗的疗效。方法选取该院2016年12月—2017年11月收治的102例宫外孕妇女,将其随机分为试验组和对照组,对照组患者只给予米非司酮片治疗,试验组患者在对照组的基础上加以甲氨蝶呤注射液配合治疗。治疗结束后观察两组的临床症状和疗效,治疗过程中记录不良反应的发生情况。结果两种药物合用的试验组患者总有效率(90.2%)明显高于对照组(31.1%)(χ~2=44.51,P<0.05),且试验组不良反应的发生率明显小于对照组(χ~2=10.18,P<0.05),安全性较高。结论两者药物合用于保守治疗宫外孕,其疗效显著,不良反应少,具有临床推广价值。

Objective This paper tries to explore the clinical effect of methotrexate combined with Mifepristone in the treatment of ectopic pregnancy. Methods 102 female ectopic pregnant women admitted to this hospital from December2016 to November 2017 were randomly divided into experimental group and control group. Patients in the control group were only treated with mifepristone tablets, and patients in the experimental group based on the control group adopted Methotrexate injection combined with treatment. At the end of treatment, the clinical symptoms and efficacy of the two groups were observed, and the occurrence of adverse reactions was recorded during the course of treatment. Results The total effective rate（90.2%） was significantly higher in the experimental group than in the control group（31.1%）（χ~2=44.51, P 〈0.05）, and the incidence of adverse reactions in the trial group was significantly lower than that in the control group（χ~2=10.18, P〈0.05）, with higher safety. Conclusion The combination of the two drugs for the conservative treatment of ectopic pregnancy is significant effect, fewer adverse reactions, with clinical promotion value.