双分子靶向药物联用的药学监护与分析

Pharmaceutical Care and Analysis of the Combined Treatment of Two Kinds of Molecular Targeting Drugs

临床药师对晚期结肠癌患者在联用西妥昔单抗和阿帕替尼治疗过程中出现重度皮疹的原因进行分析,开展药学监护,通过查阅相关指南、文献探讨联合使用分别以表皮生长因子受体和血管内皮生长因子受体为靶点的分子靶向药物治疗晚期结肠癌患者的用药安全性,提出合理用药建议,为此类分子靶向药物在临床的合理应用提供参考。

Clinical pharmacists participated in the whole drug treatment process of one advanced colon cancer patient,analyzed the cause of the severe rash after the combined treatment of cetuximab and apatinib,and then provided pharmaceutical care. The safety of the combined use of drugs targeting epidermal growth factor receptor and those targeting vascular endothelial growth factor receptor in the treatment of advanced colon cancer patients was investigated,and suggestions for rational drug use were provided for health care workers.