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化合物XD-7006对小鼠LPS致痛觉增敏的镇痛效果及其机制研究

Study on Analgesic Effect and Mechanism of XD-7006 on Hyperalgesia in Mice by Lipopolysaccharide
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摘要 目的:利用脂多糖(LPS)激发小鼠痛觉增敏反应,观察化合物XD-7006对痛觉增敏模型的影响,并进一步探讨该化合物镇痛与白介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、一氧化氮(NO)的关系。方法:随机将实验小鼠分为空白组、模型组、阿司匹林组及化合物XD-7006 80、40、20 mg/kg 6组,通过腹腔注射LPS建立疼痛增敏模型,利用冰醋酸扭体法和热板法观察该化合物的镇痛活性,通过相关试剂盒检测脑组织NO,及血浆IL-6、TNF-α含量变化。结果:化合物XD-7006在给药剂量为80、40 mg/kg,能减少冰醋酸诱导小鼠扭体次数,延长小鼠的痛阈值,抑制脑组织NO,及血浆IL-6、TNF-α的含量。结论:化合物XD-7006具有一定的镇痛活性,其机制可能是与抑制IL-6、TNF-α、NO的含量有关。
出处 《荆楚理工学院学报》 2018年第2期53-56,共4页 Journal of Jingchu University of Technology
基金 湖北省教育厅中青年人才项目(Q20174304) 荆门市科技局科研项目(YFYB2017013) 荆楚理工学院校级科研项目(YB201705)
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