急性颅脑外伤患者血浆NPY、Hcy和S100β的水平变化特点及其临床意义分析

Characteristics of the Level Changes of Plasma NPY,Hcy and S100β in Patients with Acute Craniocerebral Trauma and The Clinical Significance

目的观察急性颅脑外伤患者血浆NPY、Hcy和S100β水平,并分析其临床意义。方法选取2016年2月至2017年5月在河南省南阳市中心医院经外科接受治疗的急性颅脑外伤患者为研究对象,并根据其疾病情况分为轻症组和重症组,同时选取同期在我院接受体检的健康成年人作为对照组。观察3组研究对象细胞因子、NPY、Hcy、S100β水平和Glasgow评分的差异,分析急性颅脑损伤患者血浆NPY、Hcy和S100β水平与细胞因子和Glasgow评分的相关性。结果 3组研究对象的IL-18、IL-6、hs-CRP、NPY、Hcy、S100β水平与NIHSS评分由高到低分别重症组、轻症组和对照组(P<0.001)。经进一步两两比较,呈现与病情严重程度正相关的趋势,重症组3种细胞因子的水平均高于轻症组,轻症组高于对照组;Glasgow评分由高到低分别为对照组、轻症组和重症组,呈现与病情严重程度负相关的趋势,重症组低于轻症组,轻症组低于对照组。结论急性颅脑外伤患者血浆NPY、Hcy和S100β水平较高,且与细胞因子、Glasgow评分和NIHSS评分密切相关。

Objective To observe the levels of plasma NPY, Hcy and S100β in patients with acute craniocerebral trauma and analyze their clinical significance. Methods The patients with acute craniocerebral trauma treated in Nanyang City Center Hospital of Henan from February of 2016 to May of 2017 were selected as the research objects and divided into the mild group and severe group according to the disease severity. The other heathy adults undergoing the medical examination over the corresponding period were selected into the control group. The differences in the levels of cytokines, NPY, Hcy and S100β and the Glasgow scores among the three groups were analyzed and the correlations of the levels of plasma NPY, Hcy and S100β with cytokines and Glasgow scores were analyzed. Results The levels of IL-18, IL-6, hs-CRP, NPY, Hcy and S100β and the NIHSS scores were the highest in the severe group and the lowest in the control group, and the differences were statistically significant among the three groups （ P 〈0.001）. The results of the comparisons between groups showed that they were positively correlated with the disease severity. The levels of plasma NPY, Hcy and S100 were higher in the server group than in the mild group, and they were higher in the mild group than in the control group. The Glasgow score was the highest in the control group and the lowest in the severe group with a negative correlation with the disease severity. The Glasgow score was lower in the severe group than in the mild group, and it was lower in the mild group than in the control group. Conclusion The levels of plasma NPY, Hcy and S100β are high in patients with acute craniocerebral trauma and they are closely correlated with the levels of cytokines and the scores of Glasgow and NIHSS.