快速眼动睡眠期的阻塞型呼吸暂停与高血压

Obstructive apnea during rapid eye movement sleep and hypertension

快速眼动(REM)睡眠期阻塞型睡眠呼吸暂停(OSA)是指发生在REM期的阻塞型睡眠呼吸暂停综合征,由于REM期交感神经活性异常增高,因此发生在此期的OSA可以使交感神经活性更高,心血管功能更不稳定。目前认为REM-OSA很可能是OSA相关高血压发生的主要原因,并且也可能是目前OSA相关高血压用持续正压通气(CPAP)治疗效果不明显的重要原因。临床工作中应重视对REM-OSA的诊断和治疗,这对OSA相关高血压的防治具有重要意义。

Obstructive sleep apnea（ OSA） during rapid eye movement（ REM） sleep is defined as OSA occurring mainly in the REM sleep. Evidence shows that REM sleep is associated with abnormal higher sympathetic activity,so OSA in this period leads to even higher sympathetic activity,and thus cardiovascular instability. Recent studies have indicated that REM-OSA might be main reason for OSA induced hypertension,and this might also be the vital cause of negative or modest effect of continuous positive airway pressure（ CPAP） therapy on such hypertension. In clinical practice,more attention should be paid to the diagnosis and treatment of REM-OSA,which is of great significance for the prevention and treatment of OSA related hypertension.