脾虚、血瘀及痰饮与乏氧肿瘤微环境研究进展

Research Progress in Hypoxia Tumor Microenvironment with Spleen Deficiency, Blood Stasis and Phlegm Retention

乏氧状态是恶性肿瘤微环境最重要的特征之一,其程度与肿瘤的发展及预后密切相关。乏氧状态可促进肿瘤微环境中血管新生,导致能量代谢改变及耐药发生。近年研究表明,中医药能在某些环节干预乏氧肿瘤微环境的发生及发展,从而对肿瘤产生抑制作用。本文从脾虚、血瘀及痰饮方面,对乏氧肿瘤微环境发生、发展的中医病因、病机及中药干预的近年研究进行综述,为肿瘤临床干预及新药研发提供参考。

Hypoxia is one of the most important characteristics of malignant tumor microenvironment, and its degree is closely related to the development and prognosis of the tumor. Hypoxia promotes neovascularization in tumor microenvironment, which leads to changes of energy metabolism and the formation of drug tolerance in tumor. Studies in recent years have shown that TCM can interfere with the occurrence and development of hypoxia tumor microenvironment in certain aspects, thus inhibiting tumor growth. This article summarized recent studies on the etiology, pathogenesis, and TCM intervention for the occurrence and development of hypoxia tumor microenvironment in terms of spleen deficiency, blood stasis, and phlegm retention, and provided a reference for clinical intervention of tumors and research and development of new drugs.