大剂量奥曲肽联合兰索拉唑治疗肝硬化合并上消化道出血的临床观察

Clinical observation of high-dose Octreotide combined with Lansoprazole in treatment of liver cirrhosis complicated with upper gastrointestinal bleeding

目的:观察大剂量奥曲肽联合兰索拉唑治疗肝硬化合并上消化道出血的临床效果。方法:将90例肝硬化合并上消化道出血患者作为研究对象,按随机数字表法分为观察组与对照组两组,每组45例。对照组给予常规剂量奥曲肽联合兰索拉唑治疗,观察组则给予大剂量奥曲肽联合兰索拉唑治疗,比较两组治疗效果情况。结果:观察组止血时间、输血率、输血量和再出血发生率均明显少于对照组(P<0.05);观察组静脉曲张消失率明显高于对照组(P<0.05);治疗后,两组血小板计数均明显升高(P<0.05),STB、ALB水平均明显降低(P<0.05),且观察组血小板计数升高及STB、ALB水平降低幅度均明显大于对照组(P<0.05);观察组治疗总有效率明显高于对照组(P<0.05);两组不良反应发生率比较差异无统计学意义(P>0.05)。结论:大剂量奥曲肽联合兰索拉唑治疗肝硬化合并上消化道出血的临床效果优于常规剂量奥曲肽联合兰索拉唑治疗效果。

Objective： To analyze clinical effects of high-dose Octreotide combined with Lansoprazole in treatment of liver cirrhosis with upper gastrointestinal bleeding. Methods： Ninety patients with liver cirrhosis complicated with upper gastrointestinal hemorrhage were taken as the observation objects. According to the random number table method,these patients were divided into observation group and control group,45 cases in each group. The control group was given conventional doses of Octreotide combined with Lansoprazole treatment,while the observation group was given the high dose of Octreotide combined with Lansoprazole treatment. The treatment effects of the two groups were compared. Results： The hemostasis time,blood transfusion rate,transfusion volume,and rebleeding rate in the observation group were significantly lower than those in the control group（ P〈0.05）. The disappearance rate of varicose veins in the observation group was significantly higher than that in the control group（ P〈0.05）. After the treatment,the platelet counts of both groups increased significantly（ P〈0.05）,and the levels of STB and ALB decreased significantly（ P〈0.05）. The platelet increase and the decrease of the STB and ALB levels in the observation group were significantly greater than those in the control group（ P〈0.05）. The total effective rate in the observation group was significantly higher than that in the control group（ P〈0.05）. There was no significant difference in the incidence of adverse reactions between the two groups（ P〉0. 05）. Conclusions： High-dose Octreotide combined with Lansoprazole is more effective than conventional dose of Octreotide combined with Lansoprazole in the treatment of liver cirrhosis with upper gastrointestinal bleeding.