婴儿脓毒症血清免疫球蛋白补体水平评估严重程度的临床意义

目的探讨脓毒症婴儿血清免疫球蛋白及补体水平与脓毒症严重程度的关系，及临床应用价值。方法回顾分析98例脓毒症婴儿的临床资料，年龄1～12个月，根据儿科脓毒症定义，将患儿分为非严重脓毒症组和严重脓毒症组。采用免疫比浊法测定患者入院时当日清晨血清IgM、IgG、IgA、C3、C4水平，分析各血清免疫球蛋白及补体水平与脓毒症严重程度的关系。结果严重脓毒症组血清免疫球蛋白IgM、IgG、IgA及补体c3、c4水平均较非严重脓毒症组低，差异有统计学意义（P〈0．05），严重脓毒症纽多为≥2种血清免疫球蛋白或补体缺乏。结论脓毒症婴儿存在不同程度血清免疫球蛋白及补体缺乏，各血清免疫球蛋白及补体水平与脓毒症的严重程度密切相关，可有助于临床判断病情。

Objective To investigate the relationship between serum immunoglobulin and complement levels and the severity of sepsis in infants, as well as the clinical value. Methods 98 cases of hospitalized septic infants aged from 1-12 months were retrospective analyzed and divided into non-severe sepsis group and severe sepsis group according to the definition of pediatric sepsis series. The levels of serum IgM, IgG, IgA, C3 and C4 were measured by immunoturbidimetry on the morning of admission, the relationship between the levels of serum inlmunoglobulin and complement and the severity of＇sepsis were analyzed. Results The levels of serum immunoglobulin IgM, IgG, IgA and complement C3 and C4 in severe sepsis group were lower than those in non-severe sepsis group, the difference was statistically significant （ P〈0.05 ） . There were 2 or more than 2 kinds of serum immunoglobulin or complement deficiency in severe sepsis group. Conclusion There are different levels of serum immunoglobulin and complement deficiency in septic infants. The levels of serum immunoglobulin and complement are closely related to the severity of sepsis, which can help to predict clinical condition.