摘要
To the Editor: Plasmacytoid dendritic cells (pDCs) represent a subset of dendritic cells. There are two distinct forms of neoplasms derived from pDCs; the one is blastic plasmacytoid dendritic cell neoplasm (BPDCN) and the other is mature pDCs proliferation coexisted with myeloid tumors. The mature pDCs in myeloid tumor are characterized by a lineage-negative human leukocyte antigen (HLA)-DR^+ CD56 CD123^+CDIIc immunophenotype. Here, we describe an 83-year-old man who developed acute ,nyeloid leukemia (AML) transferred from primary myelofibrosis (PMF) coexisted with monoclonal gammopathy of undetermined significance (MGUS) and mature pDCs proliferation; however, the immunophenotype results of bone marrow (BM) showed positive CD56 expression.
To the Editor: Plasmacytoid dendritic cells (pDCs) represent a subset of dendritic cells. There are two distinct forms of neoplasms derived from pDCs; the one is blastic plasmacytoid dendritic cell neoplasm (BPDCN) and the other is mature pDCs proliferation coexisted with myeloid tumors. The mature pDCs in myeloid tumor are characterized by a lineage-negative human leukocyte antigen (HLA)-DR^+ CD56 CD123^+CDIIc immunophenotype. Here, we describe an 83-year-old man who developed acute ,nyeloid leukemia (AML) transferred from primary myelofibrosis (PMF) coexisted with monoclonal gammopathy of undetermined significance (MGUS) and mature pDCs proliferation; however, the immunophenotype results of bone marrow (BM) showed positive CD56 expression.
作者
Min Wang
Yi-Juan Chen
Li-Ru Wang
Ya-Zhe Wang
Jin Lu
Min Wang;Yi-Juan Chen;Li-Ru Wang;Ya-Zhe Wang;Jin Lu(Department of Hematology,Fu Xing Hospital,Capital Medical University,Beijing 100038,China;Department of Hematology,Peking University People's Hospital and Peking University Institute of Hematology,Beijing 100044,China)