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Plasmacytoid Dendritic Cells Proliferation Coexisted with Acute Myeloid Leukemia 被引量:1

Plasmacytoid Dendritic Cells Proliferation Coexisted with Acute Myeloid Leukemia
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摘要 To the Editor: Plasmacytoid dendritic cells (pDCs) represent a subset of dendritic cells. There are two distinct forms of neoplasms derived from pDCs; the one is blastic plasmacytoid dendritic cell neoplasm (BPDCN) and the other is mature pDCs proliferation coexisted with myeloid tumors. The mature pDCs in myeloid tumor are characterized by a lineage-negative human leukocyte antigen (HLA)-DR^+ CD56 CD123^+CDIIc immunophenotype. Here, we describe an 83-year-old man who developed acute ,nyeloid leukemia (AML) transferred from primary myelofibrosis (PMF) coexisted with monoclonal gammopathy of undetermined significance (MGUS) and mature pDCs proliferation; however, the immunophenotype results of bone marrow (BM) showed positive CD56 expression. To the Editor: Plasmacytoid dendritic cells (pDCs) represent a subset of dendritic cells. There are two distinct forms of neoplasms derived from pDCs; the one is blastic plasmacytoid dendritic cell neoplasm (BPDCN) and the other is mature pDCs proliferation coexisted with myeloid tumors. The mature pDCs in myeloid tumor are characterized by a lineage-negative human leukocyte antigen (HLA)-DR^+ CD56 CD123^+CDIIc immunophenotype. Here, we describe an 83-year-old man who developed acute ,nyeloid leukemia (AML) transferred from primary myelofibrosis (PMF) coexisted with monoclonal gammopathy of undetermined significance (MGUS) and mature pDCs proliferation; however, the immunophenotype results of bone marrow (BM) showed positive CD56 expression.
作者 Min Wang Yi-Juan Chen Li-Ru Wang Ya-Zhe Wang Jin Lu Min Wang;Yi-Juan Chen;Li-Ru Wang;Ya-Zhe Wang;Jin Lu(Department of Hematology,Fu Xing Hospital,Capital Medical University,Beijing 100038,China;Department of Hematology,Peking University People's Hospital and Peking University Institute of Hematology,Beijing 100044,China)
出处 《Chinese Medical Journal》 SCIE CAS CSCD 2018年第15期1866-1867,共2页 中华医学杂志(英文版)
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