胱天蛋白酶募集域蛋白9在非感染性炎症疾病中的研究进展

Update of caspase recruitment domain protein 9 in non - infectious inflammatory diseases

胱天蛋白酶募集域蛋白9（CARD9）是一种重要的衔接蛋白，通过蛋白-蛋白的相互作用，调节细胞内信号传递。近年来研究发现，CARD9在感染性疾病中发挥重要作用，在非感染性炎症疾病中亦明显表达，其可能参与非感染性炎症疾病的发生、发展，在其发病机制中发挥调控作用。本文简要介绍CARD9的结构及其与机体炎症信号通路的关联，重点就CARD9在心血管系统、消化系统及自身免疫系统等非感染性炎症疾病中的作用及机制的研究进展进行综述。

Caspase recruitment domain protein 9 （ CARD9 ） is a non - redundant adapter protein regulating intra - cellular signal transduetion pathway through CARD - CARD interaction. CARD9 has been widely studied in the infectious diseases, also been found to be highly expressed in non - infectious inflammatory diseases, which may be involved in the development of non - infectious inflammatory diseases and play a regulatory role in its pathogenesis. This article briefly describes the structure of CARD9 and its association with inflammatory signaling pathways in the body, focusing on the research progress of the role and mechanism of CARD9 in non - infectious inflammatory diseases of cardiovascular system, digestive system, autoimmune system and so on.