急性脑梗死合并代谢综合征患者Hs-CRP、FIB与中医证候分析

Analysis on Hs-CRP, FIB and traditional Chinese medicine syndrome in acute cerebral infarction patients combined with metabolic syndrome

目的:研究急性脑梗死患者合并代谢综合征(MS)时超敏C反应蛋白(Hs-CRP)、纤维蛋白原(FIB)的变化及中医证候的特点。方法:纳入127例急性脑梗死患者,根据是否合并代谢综合征分为2组,其中合并代谢综合征组(MS组)45例,不合并代谢综合征组(无MS组)82例,对2组患者的Hs-CRP、FIB、中医证候及神经功能缺损进行比较。结果:MS组患者的Hs-CRP、FIB较无MS组显著升高(P<0.05);MS组患者的火证分值、火证患者比例较无MS组显著升高(P<0.05);MS组气虚证患者比例较无MS组显著升高(P<0.01)。结论:急性脑梗死患者合并代谢综合征时,中医证候更容易出现火证及气虚证,且患者血中的炎性标志物Hs-CRP与凝血功能标志物FIB较无代谢综合征的患者要高。

Objective： To study the changes of hypersensitive C-reactive protein （Hs-CRP）, fibrinogen （FIB）, and TCM syndromes in patients with acute cerebral infarction with metabolic syndrome （MS）. Methods： A total of 127 patients with acute cerebral infarction were included and divided into 2 groups according to whether they had metabolic syndrome or not, including 45 patients with metabolic syndrome （MS group） and 82 patients without metabolic syndrome group （MS group）. The Hs-CRP, FIB, TCM syndromes and neurological deficits in the two groups were compared. Results： The Hs-CRP and FIB were higher in the MS group than in the MS group （P〈0.05）. Fire syndrome scores of patients were higher than those without MS （P〈0.05）, the proportion of patients with fire syndrome in MS group was higher than the group without MS （P〈0.05）, the proportion of patients with qi deficiency in MS group was higher compared with the group without MS, it was statistically significant （P〈0.01）. Conclusion： In patients with acute cerebral infarction complicated with metabolic syndrome, TCM syndromes are more prone to fire syndrome and qi deficiency syndrome, and the inflammatory markers Hs-CRP and coagulation function marker FIB in the blood of patients were higher than those without metabolic syndrome.