血清Rta蛋白及抗体在鼻咽癌早期诊断中的应用进展

Advances in Application of Serum Rta Protein and Antibodies in the Early Diagnosis of Nasopharyngeal Carcinoma

血清学检测是鼻咽癌早期诊断的重要辅助方法。Rta蛋白是EB病毒裂解立即早期基因BRLF1编码产物,是EB病毒由潜伏期转向裂解期的关键调控因子,能引起一系列的裂解早期基因的相继表达,最终引发EB病毒裂解感染。近十几年的研究表明,对血清Rta蛋白特定抗体的检测能提高鼻咽癌早期诊断阳性率,Rta蛋白有望成为鼻咽癌的早期血清学诊断指标。

Serological detection method is important in the early diagnosis of nasopharyngeal carcinoma.R transactivator（Rta）is encoded by the BRLF1 that is an immediate-early gene in initiation of the Epstein-Barr virus（EBV）from the latent state to the lytic state.It can cause sequential expression of a series of early lytic genes and eventually induce lytic infection.Most studies in the recent decades have shown that the detection of serum Rta protein-specific antibodies may be useful for the early diagnosis of nasopharyngeal carcinoma,and the Rta protein is expected to be an early diagnostic marker for nasopharyngeal carcinoma.Here,we review the research advances and application of serum Rta and its antibodies in the early diagnosis of nasopharyngeal carcinoma.