甲巯咪唑联合左甲状腺素片对甲状腺功能亢进症患者甲状腺体积及血清FT3、FT4、TSH水平的影响

Effect of Methimazole Combined with Levothyroxine on the Thyroid Volume and Serum FT3, FT4, TSH Levels of Patients with Hyperthyroidism

目的了解甲巯咪唑联合左甲状腺素片对甲状腺功能亢进症患者甲状腺体积及机体血清FT3、FT4、TSH水平的影响。方法以随机法将方便选取该院2014年1月—2016年12月收治的68例甲状腺功能亢进症分成2组:给予甲巯咪唑的34例为对照组,予以甲巯咪唑+左甲状腺素片治疗的34例为治疗组,同时观察、对比2组治疗效果。结果治疗组甲状腺体积(12.35±4.60)mL,比对照组(15.62±3.61)mL更低,(t=-3.261;P<0.05);血清FT3(4.42±1.52)pg/mL(t=5.308;P<0.05))、FT4(13.49±1.16)mmol/L水平(t=7.071;P<0.05),比对照组(3.11±0.69)pg/mL、(11.20±1.49)mmol/L高(P<0.05);而TSH水平(2.65±1.21)mIU/L,低于对照组(4.21±1.24)m IU/L,(t=-5.250;P<0.05)。结论临床治疗甲状腺功能亢进症,联用甲巯咪唑与左甲状腺素片展开治疗,可确保甲状腺体积缩小的同时,较好的改善机体血清FT3、FT4、TSH水平,具有较高的临床推广价值。

Objective To know the effect of methimazole combined with levothyroxine on the thyroid volume and serum FT3, FT4, TSH levels of patients with hyperthyroidism. Methods 68 cases of patients with hyperthyroidism admitted and treated in our hospital from January 2014 to December 2016 were convenient selected and randomly divided into two groups with 34 cases in each, the control group were treated with methimazole, while the treatment group were treated with methimazole combined with levothyroxine, and the treatment effect was compared between the two groups. Results The thyroid volume in the treatment group was lower than that in the control group, [（12.35±4.60） mL vs（15.62±3.61） mL],（t=-3.261; P〈0.05）, and the serum FT3（4.42±1.52） pg/mL（t=5.308; P〈0.05）, FT4（ 13.49±1.16）mmol/L（t=7.071; P〈0.05） were higher than those in the control group, [（3.11±0.69）pg/mL,（11.20±1.49） mmol/L]（P〈0.05）, and the TSH level was lower than that in the control group, [（ 2.65±1.21） m IU/L vs（4.21±1.24）mIU/L],（t=-5.250;P〈0.05）. Conclusion The methimazole combined with levothyroxine in treatment of hyperthyroidism can ensure the decrease of thyroid volume, and better improve the serum FT3,FT4, TSH levels, with higher clinical promotion value.