经皮给药联合口服补液盐治疗小儿轮状病毒腹泻的疗效分析

Analysis of Curative Effect of Transdermal Administration Combined with Oral Administration of Rehydration Salts in Treatment of Children with Rotavirus Diarrhea

目的评价经皮给药联合口服补液盐治疗小儿轮状病毒腹泻疗效。方法方便选取2016年6月—2017年2月该院儿科收治小儿轮状病毒腹泻90例,根据病历号分组。观察组45例,采用抗病毒药物、思密达治疗。对照组45例,安排口服补液盐治疗。观察组联合经皮给药治疗。对比两组的对象的康复进程、并发症发生情况。结果观察组腹泻好转时间、腹泻控制时间、总疗程、补液次数分别为(1.4±0.5)d、(3.1±1.1)d、(5.7±1.5)d、(10.4±2.5)次/人,低于对照组(2.2±0.6)d、(4.3±1.6)d、(7.2±2.2)d、(14.2±3.2)次/人,差异有统计学意义(t=3.56、3.80、4.15、4.40,P=0.012、0.001、0.000、0.000<0.05)。观察组并发症发生率4.44%低于对照组22.22%,差异有统计学意义(χ~2=6.15,P=0.013<0.05)。结论经皮给药联合口服补液盐治疗小儿轮状病毒腹泻,可以缩短疗程,改善预后,增进疗效。

Objective To evaluate the curative effect of transdermal administration combined with oral administration of Rehydration salts in treatment of children with rotavirus diarrhea. Methods 90 cases of children with rotavirus diarrhea were convenient selected from June 2016 to February 2017 and randomly divided into two groups with 45 cases in each, the observation group were treated with anti-viral and dioctahedral smectite therapy, while the control group took the rehydration salt orally, and the rehabilitation course and occurrence of complications were compared between the two groups. Results The diarrhea improvement time, diarrhea control time, total treatment course and rehydration frequency in the observation group were lower than those in the control group, [（1.4±0.5）d,（3.1±1.1）d,（5.7±1.5）d,（10.4±2.5）times/person vs（2.2±0.6）d,（4.3±1.6）d,（7.2±2.2）d,（14.2±3.2）times/person], and the differences were statistically significant（t=3.56, 3.80, 4.15, 4.40, P=0.012, 0.001, 0.000, 0.000 0.05）, and the incidence rate of complications in the observation group was lower than that in the control group,（4.44% vs 22.22%）, and the difference was statistically significant（χ~2=6.15, P=0.0130.05）. Conclusion The transdermal administration combined with oral administration of Rehydration salts in treatment of children with Rotavirus diarrhea can shorten the treatment course, improve the prognosis and enhance the curative effect.