布鲁杆菌性骨关节炎治疗进展

Progress on the treatment of Brucellar osteoarthritis

布鲁菌病是一种全球性分布的人畜共患病,可表现为全身多系统损害,其中布鲁杆菌性骨关节炎为布鲁菌病常见的临床表现之一。本文旨在对布鲁杆菌性骨关节炎的治疗进展作一综述。目前国内外文献中报道的治疗方式主要包括药物治疗和手术治疗,其中药物治疗国外普遍试行WHO推荐的药物治疗方案,而我国遵循的为2012年由首都医科大学附属北京地坛医院制定的《布鲁氏菌病诊疗指南(试行)》药物治疗方案,主要包括多西环素、利福平、链霉素类、喹诺酮类和头孢类。对于布鲁杆菌性骨关节炎,早期诊断以及早期、足量、足疗程药物治疗可取得良好的疗效,而对于存在严重脊柱、关节破坏的布鲁杆菌性骨关节炎则应采取手术治疗。

Brucellosis is a globally distributed zoonotic disease, which can be expressed as multiple systems damage, among which Brucellar osteoarthritis is the common clinical manifestation. This review summarized the progress of treatment for Brucellar osteoarthritis. At present, the treatment of Brucellar osteoarthritis mainly include drug treatment and surgical treatment which were reported in domestic and foreign literatures. Drug treatment plan recommended by WHO is widely selected abroad and in our country we follow the ＂Brucellosis Medical treatment program（trial edition）＂ drug treatment program developed by Beijing Ditan Hospital, Capital Medical University in 2012, which mainly includes doxycycline, rifampicin, streptomycin, quinolones and cephalosporins. Early diagnosis and early, sufficient, adequate course of drug treatment for Brucellar osteoarthritis may achieve good curative effect. Surgical treatment should be applied for brucellar osteoarthritis patients with severe spinal and joint destruction.