复方多黏菌素B软膏联合长效抗菌材料洁悠神在尖锐湿疣光动力治疗术创面中的应用

Clinical efficacy of the wound healing after photodynamic treatment of Condyloma acuminatum with compound polymyxin B ointment combined with JUC

目的观察复方多黏菌素B软膏联合长效抗菌材料洁悠神(JUC)应用于尖锐湿疣光动力治疗术创面中的疗效。方法选择2016年1月至2017年1月于本科室就诊的231名使用光动力治疗的尖锐湿疣患者,随机分为两组,在光动力治疗期间,每次光动力治疗后对照组患者局部使用硼酸溶液外敷,治疗组患者在对照组基础上,加用复方多黏菌素B软膏和长效抗菌材料JUC局部外用。结果治疗组术后疼痛发生率为5.56%,术后感染发生率为2.78%,不良反应发生率为0%,总复发率为3.7%,均低于对照组(分别为13.82%、10.57%、4.07%、10.6%),差异均有统计学意义(P均<0.05)。结论尖锐湿疣光动力治疗术后,应用复方多黏菌素B软膏联合长效抗菌材料JUC能够有效减低患者疼痛感,且复发率低,不良反应少。

Objective To investigate the effect and safety of compound polymyxin B ointment combined JUC in wound healing after topical aminolaevulinic acid-based photodynamic therapy（5-ALAPDT） for the condyloma acuminatum. Methods Total of 231 patients with condyloma acuminatum from our outpatient-room, were divided into two groups randomly. After 5 ALA-PDT therapy, patients in the control group topically used 3% boric acid solution, and patients in the treatment group topically used compound polymyxin B ointment combined with JUC besides 3% boric acid solution. Results Compared with the control group（13.82%, 10.57%, 4.07% and 10.6%）, the pain incidence rates（5.56%）, the infection incidence rates（2.78%）, the incidence rates of the scar and pigment residue（0%）, the relapse rate（3.7%） of patients in the treatment group were all with significant differences（all P〈0.05）. Conclusions Compound polymyxin B ointment combined with JUC could be used effectively and safely after 5 ALA-PDT treatment for condyloma acuminatum. The combined treatment could release the pain and the rates of recurrence and with less adverse reaction.