戊型肝炎患者血清GP73变化特征及意义

Characteristics of serum GP73 for patients with hepatitis E and its clinical significances

目的观察戊型肝炎患者血清GP73变化特征。方法分析80例健康体检者(对照组)和66例戊型肝炎患者(观察组)血清GP73水平的变化。结果对照组研究对象血清GP73水平为(38.82±15.67)ng/ml,观察组患者血清GP73为(80.06±52.33)ng/ml,较对照组显著升高,差异具有统计学意义(t=6.785、P<0.001);患者血清GP73水平与丙氨酸氨基转移酶(ALT)活性(r=0.28、P=0.015)、天门冬氨酸氨基转移酶(AST)活性(r=0.36、P=0.002)总胆红素(TBil)水平(r=0.47、P<0.001)均呈正相关,而与凝血酶原活动度(PTA)水平呈负相关(r=-0.329、P=0.004)。结论血清GP73显著升高的人群需考虑急性戊型肝炎病毒感染的可能。戊型肝炎患者的血清GP73水平可能与肝功能损伤程度具有一定的相关性。

Objective To investigate the variable characteristics of serum GP73 for patients with hepatitis E. Methods The changes of GP73 level in serum of 80 healthy subjects（control group） and 66 patients with hepatitis E were detected by quantitative enzyme-linked immunosorbent assay. Results The median level of serum GP73 for patients with hepatitis E（80.06 ± 52.33 ng/ml） was significantly increased than that of 80 healthy control subjects（38.82 ± 15.67 ng/ml）, with significant difference（t = 6.785, P〈0.0001）. The level of serum GP73 in patients with hepatitis E had positive correlation with the serum activity of alanine aminotransferase（ALT）（r = 0.28, P = 0.015）, aspartate aminotransferase（AST）（r = 0.36, P = 0.002） and the level of serum total bilirubin（TBil）（r = 0.47, P〈0.001）. While it had negative correlation with the prothrombin time activity（PTA）（r =-0.329, P = 0.004）. Conclusions The possibility of acute hepatitis E infection should be considered for those who with significangly elevated serum GP73. Serum GP73 levels in patients with hepatitis E may be correlated with liver damage.